Quantitative CT measures of emphysema and airway wall thickness are related to D(L)CO

TY - JOUR

T1 - Quantitative CT measures of emphysema and airway wall thickness are related to D(L)CO

AU - Grydeland, Thomas B

AU - Thorsen, Einar

AU - Dirksen, Asger

AU - Jensen, Robert

AU - Coxson, Harvey O

AU - Pillai, Sreekumar G

AU - Sharma, Sanjay

AU - Eide, Geir Egil

AU - Gulsvik, Amund

AU - Bakke, Per S

N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.

PY - 2011/3

Y1 - 2011/3

N2 - There is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (DLCO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. Study question: What is the relationship between DLCO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? Methods: We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas <-950 HU (%LAA) and standardized airway wall thickness (AWT-Pi10). Results: Multiple linear regression analyses showed significant associations between DLCO and both %LAA and AWT-Pi10 in the COPD group. The adjusted regression coefficients (SE) for DLCO (mmol min-1 kPa-1) were -1.15 (0.11) per 10% increase in %LAA and 0.08 (0.03) per 0.1 mm increase in AWT-Pi10, and the models' adjusted R2 was 0.65 and 0.49, respectively. Conclusions: CT measured emphysema explains a large fraction of the variation of DLCO among COPD subjects, and more so in men. Airway wall thickness is also significantly associated with DLCO, but explains a much smaller fraction of the variation.

AB - There is limited knowledge on the relationship between diffusing capacity of the lung for carbon monoxide (DLCO) and quantitative computed tomography (CT) measures of emphysema and airway wall thickness. Study question: What is the relationship between DLCO and the quantitative CT measures of emphysema and airway wall thickness in subjects with and without COPD? Methods: We included 288 COPD subjects (70% men) and 425 non-COPD subjects (54% men). All subjects were current or ex-smokers older than 40 years and all subjects underwent spirometry, diffusing capacity tests and CT examination. Quantitative CT measures included % low attenuation areas <-950 HU (%LAA) and standardized airway wall thickness (AWT-Pi10). Results: Multiple linear regression analyses showed significant associations between DLCO and both %LAA and AWT-Pi10 in the COPD group. The adjusted regression coefficients (SE) for DLCO (mmol min-1 kPa-1) were -1.15 (0.11) per 10% increase in %LAA and 0.08 (0.03) per 0.1 mm increase in AWT-Pi10, and the models' adjusted R2 was 0.65 and 0.49, respectively. Conclusions: CT measured emphysema explains a large fraction of the variation of DLCO among COPD subjects, and more so in men. Airway wall thickness is also significantly associated with DLCO, but explains a much smaller fraction of the variation.

U2 - http://dx.doi.org/10.1016/j.rmed.2010.10.018

DO - http://dx.doi.org/10.1016/j.rmed.2010.10.018

M3 - Journal article

SN - 0954-6111

VL - 105

SP - 343

EP - 351

JO - Respiratory Medicine

JF - Respiratory Medicine

IS - 3

ER -