TY - JOUR
T1 - Quantification of myocardial perfusion using cardiac magnetic resonance imaging correlates significantly to rubidium-82 positron emission tomography in patients with severe coronary artery disease
T2 - A preliminary study
AU - Qayyum, Abbas A
AU - Hasbak, Philip
AU - Larsson, Henrik B W
AU - Christensen, Thomas E
AU - Ghotbi, Adam A
AU - Mathiasen, Anders B
AU - Vejlstrup, Niels G
AU - Kjaer, Andreas
AU - Kastrup, Jens
N1 - Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
PY - 2014/7
Y1 - 2014/7
N2 - Introduction Aim was to compare absolute myocardial perfusion using cardiac magnetic resonance imaging (CMRI) based on Tikhonov's procedure of deconvolution and rubidium-82 positron emission tomography (Rb-82 PET). Materials and methods Fourteen patients with coronary artery stenosis underwent rest and adenosine stress imaging by 1.5-Tesla MR Scanner and a mCT/PET 64-slice Scanner. CMRI were analyzed based on Tikhonov's procedure of deconvolution without specifying an explicit compartment model using our own software. PET images were analyzed using standard clinical software. CMRI and PET data was compared with Spearman's rho and Bland-Altman analysis. Results CMRI results were strongly and significantly correlated with PET results for the absolute global myocardial perfusion differences (r = 0.805, p = 0.001) and for global myocardial perfusion reserve (MPR) (r = 0.886, p < 0.001). At vessel territorial level, CMRI results were also significantly correlated with absolute PET myocardial perfusion differences (r = 0.737, p < 0.001) and MPR (r = 0.818, p < 0.001). Each vessel territory had similar strong correlation for absolute myocardial perfusion differences (right coronary artery (RCA): r = 0.787, p = 0.001; left anterior descending artery (LAD): r = 0.796, p = 0.001; left circumflex artery (LCX): r = 0.880, p < 0.001) and for MPR (RCA: r = 0.895, p < 0.001; LAD: r = 0.886, p < 0.001; LCX: r = 0.886, p < 0.001). Conclusion On a global and vessel territorial basis, CMRI-measured absolute myocardial perfusion differences and MPR were strongly and significantly correlated with the Rb-82 PET findings.
AB - Introduction Aim was to compare absolute myocardial perfusion using cardiac magnetic resonance imaging (CMRI) based on Tikhonov's procedure of deconvolution and rubidium-82 positron emission tomography (Rb-82 PET). Materials and methods Fourteen patients with coronary artery stenosis underwent rest and adenosine stress imaging by 1.5-Tesla MR Scanner and a mCT/PET 64-slice Scanner. CMRI were analyzed based on Tikhonov's procedure of deconvolution without specifying an explicit compartment model using our own software. PET images were analyzed using standard clinical software. CMRI and PET data was compared with Spearman's rho and Bland-Altman analysis. Results CMRI results were strongly and significantly correlated with PET results for the absolute global myocardial perfusion differences (r = 0.805, p = 0.001) and for global myocardial perfusion reserve (MPR) (r = 0.886, p < 0.001). At vessel territorial level, CMRI results were also significantly correlated with absolute PET myocardial perfusion differences (r = 0.737, p < 0.001) and MPR (r = 0.818, p < 0.001). Each vessel territory had similar strong correlation for absolute myocardial perfusion differences (right coronary artery (RCA): r = 0.787, p = 0.001; left anterior descending artery (LAD): r = 0.796, p = 0.001; left circumflex artery (LCX): r = 0.880, p < 0.001) and for MPR (RCA: r = 0.895, p < 0.001; LAD: r = 0.886, p < 0.001; LCX: r = 0.886, p < 0.001). Conclusion On a global and vessel territorial basis, CMRI-measured absolute myocardial perfusion differences and MPR were strongly and significantly correlated with the Rb-82 PET findings.
KW - Adult
KW - Aged
KW - Blood Flow Velocity
KW - Coronary Artery Disease
KW - Coronary Circulation
KW - Female
KW - Humans
KW - Magnetic Resonance Angiography
KW - Magnetic Resonance Imaging, Cine
KW - Male
KW - Middle Aged
KW - Myocardial Perfusion Imaging
KW - Positron-Emission Tomography
KW - Radiopharmaceuticals
KW - Reproducibility of Results
KW - Rubidium Radioisotopes
KW - Sensitivity and Specificity
KW - Statistics as Topic
U2 - 10.1016/j.ejrad.2014.04.004
DO - 10.1016/j.ejrad.2014.04.004
M3 - Journal article
C2 - 24815746
SN - 0720-048X
VL - 83
SP - 1120
EP - 1128
JO - European Journal of Radiology
JF - European Journal of Radiology
IS - 7
ER -