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Quantification of 16 QT-prolonging Drugs and Metabolites in Human Postmortem Blood and Cardiac Tissue Using UPLC-MS-MS
Christian R Mikkelsen, Jakob Jornil, Ljubica V Andersen,
Jytte Banner
, Jørgen B Hasselstrøm
Afdeling for Retspatologi
5
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Keyphrases
High Performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS)
100%
Blood Tissue
100%
Cardiac Tissue
100%
Postmortem Blood
100%
Analytical Method
50%
Mental Illness
50%
Whole Blood
50%
Therapeutic Concentrations
25%
Prescription Drugs
25%
Treatment Risk
25%
Limit of Detection
25%
Limit of Quantification
25%
Matrix Effect
25%
Protein Precipitation
25%
Authentic Cases
25%
Deuterated Internal Standard
25%
Cardiac Toxicity
25%
Method Validation
25%
Pharmacology, Toxicology and Pharmaceutical Science
Ultra High Performance Liquid Chromatography
100%
Cardiotoxicity
100%
Prescription Drug
100%
Food Science
Tandem Mass Spectrometry
100%
Ultra High Performance Liquid Chromatography
100%