Protein sequences bound to mineral surfaces persist into deep time

Beatrice Demarchi, Shaun Hall, Teresa Roncal-Herrero, Colin L. Freeman, Jos Woolley, Molly K. Crisp, Julie Wilson, Anna Katerina Fotakis, Roman Fischer, Benedikt M. Kessler, Rosa Rakownikow Jersie-Christensen, Jesper Velgaard Olsen, James Haile, Jessica Thomas, Curtis W. Marean, John Parkington, Samantha Presslee, Julia Lee-Thorp, Peter Ditchfield, Jacqueline F. HamiltonMartyn W. Ward, Chunting Michelle Wang, Marvin D. Shaw, Terry Harrison, Manuel Domínguez-Rodrigo, Ross D. E. MacPhee, Amandus Kwekason, Michaela Ecker, Liora Kolska Horwitz, Michael Chazan, Roland Kröger, Jane Thomas-Oates, John H. Harding, Enrico Cappellini, Kirsty Penkman, Matthew James Collins

    94 Citationer (Scopus)
    143 Downloads (Pure)

    Abstract

    Proteins persist longer in the fossil record than DNA, but the longevity, survival mechanisms and substrates remain contested. Here, we demonstrate the role of mineral binding in preserving the protein sequence in ostrich (Struthionidae) eggshell, including from the palaeontological sites of Laetoli (3.8 Ma) and Olduvai Gorge (1.3 Ma) in Tanzania. By tracking protein diagenesis back in time we find consistent patterns of preservation, demonstrating authenticity of the surviving sequences. Molecular dynamics simulations of struthiocalcin-1 and -2, the dominant proteins within the eggshell, reveal that distinct domains bind to the mineral surface. It is the domain with the strongest calculated binding energy to the calcite surface that is selectively preserved. Thermal age calculations demonstrate that the Laetoli and Olduvai peptides are 50 times older than any previously authenticated sequence (equivalent to ~16 Ma at a constant 10°C).

    OriginalsprogEngelsk
    Artikelnummere17092
    TidsskrifteLife
    Vol/bind5
    Antal sider50
    ISSN2050-084X
    DOI
    StatusUdgivet - 27 sep. 2016

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