Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase

Christina Aaen Andresen; Stine Smedegaard; Kathrine Beck Sylvestersen; Charlotte Svensson; Diego Iglesias-Gato; Giuseppe Cazzamali; Tine Kragh Nielsen; Michael Lund Nielsen; Amilcar Flores Morales

doi:10.1074/jbc.M113.534602

Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase

Christina Aaen Andresen, Stine Smedegaard, Kathrine Beck Sylvestersen, Charlotte Svensson, Diego Iglesias-Gato, Giuseppe Cazzamali, Tine Kragh Nielsen, Michael Lund Nielsen, Amilcar Flores Morales

29 Citationer (Scopus)

Abstract

Background: The biological function of the ASB family of ubiquitin ligases is poorly characterized. Results: A family-wide analysis of ASB-associated proteins by mass spectrometry identified novel interactors. Conclusion: ASB proteins can associate in multimeric complexes. Asb11 ubiquitinates Ribophorin 1 and regulates its turnover. Significance: This data resource will facilitate the characterization of the biological function of ASB proteins.

Originalsprog	Engelsk
Tidsskrift	The Journal of Biological Chemistry
Vol/bind	289
Udgave nummer	4
Sider (fra-til)	2043-2054
Antal sider	12
ISSN	0021-9258
DOI	https://doi.org/10.1074/jbc.M113.534602
Status	Udgivet - 24 jan. 2014

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10.1074/jbc.M113.534602

Citationsformater

Andresen, C. A., Smedegaard, S., Sylvestersen, K. B., Svensson, C., Iglesias-Gato, D., Cazzamali, G., Nielsen, T. K., Nielsen, M. L., & Flores Morales, A. (2014). Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase. The Journal of Biological Chemistry, 289(4), 2043-2054. https://doi.org/10.1074/jbc.M113.534602

Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase. / Andresen, Christina Aaen; Smedegaard, Stine; Sylvestersen, Kathrine Beck et al.

I: The Journal of Biological Chemistry, Bind 289, Nr. 4, 24.01.2014, s. 2043-2054.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Andresen, CA, Smedegaard, S, Sylvestersen, KB, Svensson, C, Iglesias-Gato, D, Cazzamali, G, Nielsen, TK, Nielsen, ML & Flores Morales, A 2014, 'Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase', The Journal of Biological Chemistry, bind 289, nr. 4, s. 2043-2054. https://doi.org/10.1074/jbc.M113.534602

Andresen CA, Smedegaard S, Sylvestersen KB, Svensson C, Iglesias-Gato D, Cazzamali G et al. Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase. The Journal of Biological Chemistry. 2014 jan. 24;289(4):2043-2054. doi: 10.1074/jbc.M113.534602

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abstract = "Background: The biological function of the ASB family of ubiquitin ligases is poorly characterized. Results: A family-wide analysis of ASB-associated proteins by mass spectrometry identified novel interactors. Conclusion: ASB proteins can associate in multimeric complexes. Asb11 ubiquitinates Ribophorin 1 and regulates its turnover. Significance: This data resource will facilitate the characterization of the biological function of ASB proteins.",

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AU - Andresen, Christina Aaen

AU - Smedegaard, Stine

AU - Sylvestersen, Kathrine Beck

AU - Svensson, Charlotte

AU - Iglesias-Gato, Diego

AU - Cazzamali, Giuseppe

AU - Nielsen, Tine Kragh

AU - Nielsen, Michael Lund

AU - Flores Morales, Amilcar

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AB - Background: The biological function of the ASB family of ubiquitin ligases is poorly characterized. Results: A family-wide analysis of ASB-associated proteins by mass spectrometry identified novel interactors. Conclusion: ASB proteins can associate in multimeric complexes. Asb11 ubiquitinates Ribophorin 1 and regulates its turnover. Significance: This data resource will facilitate the characterization of the biological function of ASB proteins.

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DO - 10.1074/jbc.M113.534602

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Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase

Abstract

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