Prognostic value of 18F-fludeoxyglucose uptake in 287 patients with head and neck squamous cell carcinoma

TY - JOUR

T1 - Prognostic value of 18F-fludeoxyglucose uptake in 287 patients with head and neck squamous cell carcinoma

AU - Rasmussen, Jacob H

AU - Vogelius, Ivan R

AU - Fischer, Barbara M

AU - Friborg, Jeppe

AU - Aznar, Marianne C

AU - Persson, Gitte F

AU - Håkansson, Katrin

AU - Kristensen, Claus A

AU - Bentzen, Søren M

AU - Specht, Lena

N1 - © 2014 Wiley Periodicals, Inc.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - BACKGROUND: The prognostic value of 18F-Fludeoxyglucose (FDG) uptake could be due to its association with already known clinical risk factors.METHODS: Correlation between FDG uptake metrics and other known risk factors from 287 patients were analyzed. Time to any failure was analyzed using Cox proportional hazards model stratified by tumor subsite. The resulting multivariate prognostic model was used to generate a table of 2-year freedom from failure estimates with confidence intervals (CIs).RESULTS: Increasing values of standardized uptake value maximum (SUVmax) correlated with other known risk factors. The reduced Cox model included SUVmax (hazard ratio [HR] = 1.34), cisplatin (HR = 0.37), smoking status (HR = 1.49), and gross target volume (GTV; HR = 1.74) as significant prognostic factors. Including SUVmax in the model changed the 2-year failure estimate by more than 10% for a quarter of the patients (23%).CONCLUSION: FDG uptake retains statistical significance in a multivariate analysis and has clinically relevant prognostic impact. We developed a prognostic model for risk stratification of patients in a clinical setting.

AB - BACKGROUND: The prognostic value of 18F-Fludeoxyglucose (FDG) uptake could be due to its association with already known clinical risk factors.METHODS: Correlation between FDG uptake metrics and other known risk factors from 287 patients were analyzed. Time to any failure was analyzed using Cox proportional hazards model stratified by tumor subsite. The resulting multivariate prognostic model was used to generate a table of 2-year freedom from failure estimates with confidence intervals (CIs).RESULTS: Increasing values of standardized uptake value maximum (SUVmax) correlated with other known risk factors. The reduced Cox model included SUVmax (hazard ratio [HR] = 1.34), cisplatin (HR = 0.37), smoking status (HR = 1.49), and gross target volume (GTV; HR = 1.74) as significant prognostic factors. Including SUVmax in the model changed the 2-year failure estimate by more than 10% for a quarter of the patients (23%).CONCLUSION: FDG uptake retains statistical significance in a multivariate analysis and has clinically relevant prognostic impact. We developed a prognostic model for risk stratification of patients in a clinical setting.

KW - Carcinoma, Squamous Cell

KW - Cohort Studies

KW - Denmark

KW - Disease-Free Survival

KW - Female

KW - Fluorodeoxyglucose F18

KW - Head and Neck Neoplasms

KW - Hospitals, University

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Multivariate Analysis

KW - Positron-Emission Tomography

KW - Prognosis

KW - Proportional Hazards Models

KW - Radiotherapy, Intensity-Modulated

KW - Retrospective Studies

KW - Risk Factors

KW - Survival Analysis

KW - Treatment Outcome

U2 - 10.1002/hed.23745

DO - 10.1002/hed.23745

M3 - Journal article

C2 - 24801812

SN - 1043-3074

VL - 37

SP - 1274

EP - 1281

JO - Head & Neck (Print Edition)

JF - Head & Neck (Print Edition)

IS - 9

ER -