Abstract
Breast cancer cells were recently found to produce syncytin, an endogenous retroviral protein implicated in cell fusion, immune regulation, and nitric oxide synthase expression. To determine whether syncytin has a prognostic role in breast cancer, we investigated a series of 165 premenopausal lymph node-negative women for syncytin expression using an immunocytochemical scoring system. Results were analyzed with the Kaplan-Meier method and with the Cox proportional hazard model. Syncytin expression was observed in 38% of the patients, and the degree of syncytin expression constituted a positive prognostic indicator for recurrence-free survival. In addition, we examined a second series of 54 consecutively operated breast cancer patients of all categories and the results supported the conclusions made from the first study. Thus, syncytin expression constitutes a positive prognostic factor in breast cancer - a phenomenon that may be related to the involvement of syncytin in mediating fusions between breast cancer cells and entodhelial cells.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Human Pathology |
| Vol/bind | 38 |
| Udgave nummer | 5 |
| Sider (fra-til) | 726-731 |
| Antal sider | 6 |
| ISSN | 0046-8177 |
| DOI | |
| Status | Udgivet - 2007 |
Emneord
- Det tidligere LIFE
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