Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis

O Geisenberger; M Givskov; K Riedel; N Høiby; B Tümmler; Leo Eberl

Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis

O Geisenberger, M Givskov, K Riedel, N Høiby, B Tümmler, Leo Eberl

76 Citationer (Scopus)

Abstract

The N-acyl-L-homoserine lactones (AHLs) produced by sequential Pseudomonas aeruginosa isolates from chronically infected patients with cystic fibrosis were analyzed by thin-layer chromatography. It is demonstrated that both the amounts and the types of molecules synthesized by isolates from patients who were monitored over periods of up to 11 years do not change significantly during chronic colonization. However, in the case of a patient who became co-infected with an AHL-producing Burkholderia cepacia strain a dramatic reduction in the amounts of AHLs produced by the co-residing P. aeruginosa isolates was observed.

Originalsprog	Engelsk
Tidsskrift	F E M S Microbiology Letters
Vol/bind	184
Udgave nummer	2
Sider (fra-til)	273-8
Antal sider	6
ISSN	0378-1097
Status	Udgivet - 2000

Citationsformater

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title = "Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis",

abstract = "The N-acyl-L-homoserine lactones (AHLs) produced by sequential Pseudomonas aeruginosa isolates from chronically infected patients with cystic fibrosis were analyzed by thin-layer chromatography. It is demonstrated that both the amounts and the types of molecules synthesized by isolates from patients who were monitored over periods of up to 11 years do not change significantly during chronic colonization. However, in the case of a patient who became co-infected with an AHL-producing Burkholderia cepacia strain a dramatic reduction in the amounts of AHLs produced by the co-residing P. aeruginosa isolates was observed.",

keywords = "4-Butyrolactone, Burkholderia Infections, Burkholderia cepacia, Chromatography, Thin Layer, Chronic Disease, Cystic Fibrosis, Gene Expression Regulation, Bacterial, Humans, Lung Diseases, Pseudomonas Infections, Pseudomonas aeruginosa, Signal Transduction",

author = "O Geisenberger and M Givskov and K Riedel and N H{\o}iby and B T{\"u}mmler and Leo Eberl",

year = "2000",

language = "English",

volume = "184",

pages = "273--8",

journal = "F E M S Microbiology Letters",

issn = "0378-1097",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis

AU - Geisenberger, O

AU - Givskov, M

AU - Riedel, K

AU - Høiby, N

AU - Tümmler, B

AU - Eberl, Leo

PY - 2000

Y1 - 2000

N2 - The N-acyl-L-homoserine lactones (AHLs) produced by sequential Pseudomonas aeruginosa isolates from chronically infected patients with cystic fibrosis were analyzed by thin-layer chromatography. It is demonstrated that both the amounts and the types of molecules synthesized by isolates from patients who were monitored over periods of up to 11 years do not change significantly during chronic colonization. However, in the case of a patient who became co-infected with an AHL-producing Burkholderia cepacia strain a dramatic reduction in the amounts of AHLs produced by the co-residing P. aeruginosa isolates was observed.

AB - The N-acyl-L-homoserine lactones (AHLs) produced by sequential Pseudomonas aeruginosa isolates from chronically infected patients with cystic fibrosis were analyzed by thin-layer chromatography. It is demonstrated that both the amounts and the types of molecules synthesized by isolates from patients who were monitored over periods of up to 11 years do not change significantly during chronic colonization. However, in the case of a patient who became co-infected with an AHL-producing Burkholderia cepacia strain a dramatic reduction in the amounts of AHLs produced by the co-residing P. aeruginosa isolates was observed.

KW - 4-Butyrolactone

KW - Burkholderia Infections

KW - Burkholderia cepacia

KW - Chromatography, Thin Layer

KW - Chronic Disease

KW - Cystic Fibrosis

KW - Gene Expression Regulation, Bacterial

KW - Humans

KW - Lung Diseases

KW - Pseudomonas Infections

KW - Pseudomonas aeruginosa

KW - Signal Transduction

M3 - Journal article

C2 - 10713433

SN - 0378-1097

VL - 184

SP - 273

EP - 278

JO - F E M S Microbiology Letters

JF - F E M S Microbiology Letters

IS - 2

ER -

Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis

Abstract

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Citationsformater