@article{dbe98caf63e149e29a285085d2b12b47,
title = "Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors",
abstract = "A range of new C-1 modified derivatives of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol has been synthesised and their biological activities probed with the beta-glucosidase from Agrobacterium sp. Ki values are compared with those of previously prepared close relatives. Findings suggest dramatic effects exerted by the aglycon binding site on substrate/inhibitor binding.",
keywords = "Binding, Competitive, Enzyme Inhibitors, Imino Pyranoses, Mannitol, Molecular Structure, Rhizobium, Structure-Activity Relationship, beta-Glucosidase",
author = "Wrodnigg, {Tanja M} and Frederik Diness and Christoph Gruber and Herwig H{\"a}usler and Inge Lundt and Karen Rupitz and Steiner, {Andreas J} and St{\"u}tz, {Arnold E} and Tarling, {Chris A} and Withers, {Stephen G} and Heidrun W{\"o}lfler",
year = "2004",
month = jul,
day = "1",
doi = "10.1016/j.bmc.2004.04.037",
language = "English",
volume = "12",
pages = "3485--95",
journal = "Bioorganic & Medicinal Chemistry",
issn = "0968-0896",
publisher = "Pergamon Press",
number = "13",
}