Probabilistic expert systems for handling artifacts in complex DNA mixtures

TY - JOUR

T1 - Probabilistic expert systems for handling artifacts in complex DNA mixtures

AU - Cowell, R. G.

AU - Lauritzen, S. L.

AU - Mortera, J.

PY - 2011/6

Y1 - 2011/6

N2 - This paper presents a coherent probabilistic framework for taking account of allelic dropout, stutter bands and silent alleles when interpreting STR DNA profiles from a mixture sample using peak size information arising from a PCR analysis. This information can be exploited for evaluating the evidential strength for a hypothesis that DNA from a particular person is present in the mixture. It extends an earlier Bayesian network approach that ignored such artifacts. We illustrate the use of the extended network on a published casework example.

AB - This paper presents a coherent probabilistic framework for taking account of allelic dropout, stutter bands and silent alleles when interpreting STR DNA profiles from a mixture sample using peak size information arising from a PCR analysis. This information can be exploited for evaluating the evidential strength for a hypothesis that DNA from a particular person is present in the mixture. It extends an earlier Bayesian network approach that ignored such artifacts. We illustrate the use of the extended network on a published casework example.

U2 - 10.1016/j.fsigen.2010.03.008

DO - 10.1016/j.fsigen.2010.03.008

M3 - Journal article

C2 - 20452303

SN - 1872-4973

VL - 5

SP - 202

EP - 209

JO - Forensic Science International: Genetics

JF - Forensic Science International: Genetics

IS - 3

ER -