Primary pneumocystis infection in infants hospitalized with acute respiratory tract infection

Hans Henrik Larsen; Marie-Louise von Linstow; Bettina Lundgren; Birthe Høgh; Henrik Westh; Jens D Lundgren

Primary pneumocystis infection in infants hospitalized with acute respiratory tract infection

Hans Henrik Larsen, Marie-Louise von Linstow, Bettina Lundgren, Birthe Høgh, Henrik Westh, Jens D Lundgren

55 Citationer (Scopus)

Abstract

Acquisition of Pneumocystis jirovecii infection early in life has been confirmed by serologic studies. However, no evidence of clinical illness correlated with the primary infection has been found in immunocompetent children. We analyzed 458 nasopharyngeal aspirates from 422 patients hospitalized with 431 episodes of acute respiratory tract infection (RTI) by using a real-time PCR assay. In 68 episodes in 67 infants, P. jirovecii was identified. The odds ratio (95% confidence interval) of a positive signal compared with the first quartile of age (7-49 days) was 47.4 (11.0-203), 8.7 (1.9-39.7), and 0.6 (0.1-6.7) for infants in the second (50-112 days), third (113-265 days), and fourth (268-4,430 days) age quartiles, respectively. Infants with an episode of upper RTI (URTI) were 2.0 (1.05-3.82) times more likely to harbor P. jirovecii than infants with a lower RTI. P. jirovecii may manifest itself as a self-limiting URTI in infants, predominantly those 1.5-4 months of age.
Udgivelsesdato: 2007-Jan

Originalsprog	Engelsk
Tidsskrift	Emerging Infectious Diseases (Print Edition)
Vol/bind	13
Udgave nummer	1
Sider (fra-til)	66-72
Antal sider	7
ISSN	1080-6040
Status	Udgivet - 2007

Citationsformater

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title = "Primary pneumocystis infection in infants hospitalized with acute respiratory tract infection",

abstract = "Acquisition of Pneumocystis jirovecii infection early in life has been confirmed by serologic studies. However, no evidence of clinical illness correlated with the primary infection has been found in immunocompetent children. We analyzed 458 nasopharyngeal aspirates from 422 patients hospitalized with 431 episodes of acute respiratory tract infection (RTI) by using a real-time PCR assay. In 68 episodes in 67 infants, P. jirovecii was identified. The odds ratio (95% confidence interval) of a positive signal compared with the first quartile of age (7-49 days) was 47.4 (11.0-203), 8.7 (1.9-39.7), and 0.6 (0.1-6.7) for infants in the second (50-112 days), third (113-265 days), and fourth (268-4,430 days) age quartiles, respectively. Infants with an episode of upper RTI (URTI) were 2.0 (1.05-3.82) times more likely to harbor P. jirovecii than infants with a lower RTI. P. jirovecii may manifest itself as a self-limiting URTI in infants, predominantly those 1.5-4 months of age.",

keywords = "Denmark, Female, Humans, Infant, Infant, Newborn, Male, Pneumocystis Infections, Respiratory Tract Infections, Retrospective Studies",

author = "Larsen, {Hans Henrik} and {von Linstow}, Marie-Louise and Bettina Lundgren and Birthe H{\o}gh and Henrik Westh and Lundgren, {Jens D}",

year = "2007",

language = "English",

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TY - JOUR

T1 - Primary pneumocystis infection in infants hospitalized with acute respiratory tract infection

AU - Larsen, Hans Henrik

AU - von Linstow, Marie-Louise

AU - Lundgren, Bettina

AU - Høgh, Birthe

AU - Westh, Henrik

AU - Lundgren, Jens D

PY - 2007

Y1 - 2007

N2 - Acquisition of Pneumocystis jirovecii infection early in life has been confirmed by serologic studies. However, no evidence of clinical illness correlated with the primary infection has been found in immunocompetent children. We analyzed 458 nasopharyngeal aspirates from 422 patients hospitalized with 431 episodes of acute respiratory tract infection (RTI) by using a real-time PCR assay. In 68 episodes in 67 infants, P. jirovecii was identified. The odds ratio (95% confidence interval) of a positive signal compared with the first quartile of age (7-49 days) was 47.4 (11.0-203), 8.7 (1.9-39.7), and 0.6 (0.1-6.7) for infants in the second (50-112 days), third (113-265 days), and fourth (268-4,430 days) age quartiles, respectively. Infants with an episode of upper RTI (URTI) were 2.0 (1.05-3.82) times more likely to harbor P. jirovecii than infants with a lower RTI. P. jirovecii may manifest itself as a self-limiting URTI in infants, predominantly those 1.5-4 months of age.

AB - Acquisition of Pneumocystis jirovecii infection early in life has been confirmed by serologic studies. However, no evidence of clinical illness correlated with the primary infection has been found in immunocompetent children. We analyzed 458 nasopharyngeal aspirates from 422 patients hospitalized with 431 episodes of acute respiratory tract infection (RTI) by using a real-time PCR assay. In 68 episodes in 67 infants, P. jirovecii was identified. The odds ratio (95% confidence interval) of a positive signal compared with the first quartile of age (7-49 days) was 47.4 (11.0-203), 8.7 (1.9-39.7), and 0.6 (0.1-6.7) for infants in the second (50-112 days), third (113-265 days), and fourth (268-4,430 days) age quartiles, respectively. Infants with an episode of upper RTI (URTI) were 2.0 (1.05-3.82) times more likely to harbor P. jirovecii than infants with a lower RTI. P. jirovecii may manifest itself as a self-limiting URTI in infants, predominantly those 1.5-4 months of age.

KW - Denmark

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Pneumocystis Infections

KW - Respiratory Tract Infections

KW - Retrospective Studies

M3 - Journal article

C2 - 17370517

SN - 1080-6040

VL - 13

SP - 66

EP - 72

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 1

ER -

Primary pneumocystis infection in infants hospitalized with acute respiratory tract infection

Abstract

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