TY - JOUR
T1 - PREVIEW
T2 - Prevention of diabetes through lifestyle intervention and population studies in Europe and around the world. Design, methods, and baseline participant description of an adult cohort enrolled into a three-year randomised clinical trial
AU - Fogelholm, Mikael
AU - Larsen, Thomas Meinert
AU - Westerterp-Plantenga, Margriet
AU - Macdonald, Ian
AU - Martinez, J Alfredo
AU - Boyadjieva, Nadka
AU - Poppitt, Sally
AU - Schlicht, Wolfgang
AU - Stratton, Gareth
AU - Sundvall, Jouko
AU - Lam, Tony
AU - Jalo, Elli
AU - Christensen, Pia
AU - Drummen, Mathijs
AU - Simpson, Elizabeth M
AU - Navas-Carretero, Santiago
AU - Handjieva-Darlenska, Teodora
AU - Muirhead, Roslyn
AU - Silvestre, Marta P
AU - Kahlert, Daniela
AU - Pastor-Sanz, Laura
AU - Brand-Miller, Jennie
AU - Raben, Anne
N1 - CURIS 2017 NEXS 176
PY - 2017/6/20
Y1 - 2017/6/20
N2 - Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find the most effective lifestyle (diet and physical activity) for the prevention of T2D, in overweight and obese participants with increased risk for T2D. The study is a three-year multi-centre, 2 × 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity physical activity on the incidence of T2D and the related clinical end-points are investigated. The intervention started with a two-month weight reduction using a low-calorie diet, followed by a randomised 34-month weight maintenance phase comprising four treatment arms. Eight intervention centres are participating (Denmark, Finland, United Kingdom, The Netherlands, Spain, Bulgaria, Australia, and New Zealand). Data from blood specimens, urine, faeces, questionnaires, diaries, body composition assessments, and accelerometers are collected at months 0, 2, 6, 12, 18, 24, and 36. In total, 2326 adults were recruited. The mean age was 51.6 (SD 11.6) years, 67% were women. PREVIEW is, to date, the largest multinational trial to address the prevention of T2D in pre-diabetic adults through diet and exercise intervention. Participants will complete the final intervention in March, 2018.
AB - Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find the most effective lifestyle (diet and physical activity) for the prevention of T2D, in overweight and obese participants with increased risk for T2D. The study is a three-year multi-centre, 2 × 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity physical activity on the incidence of T2D and the related clinical end-points are investigated. The intervention started with a two-month weight reduction using a low-calorie diet, followed by a randomised 34-month weight maintenance phase comprising four treatment arms. Eight intervention centres are participating (Denmark, Finland, United Kingdom, The Netherlands, Spain, Bulgaria, Australia, and New Zealand). Data from blood specimens, urine, faeces, questionnaires, diaries, body composition assessments, and accelerometers are collected at months 0, 2, 6, 12, 18, 24, and 36. In total, 2326 adults were recruited. The mean age was 51.6 (SD 11.6) years, 67% were women. PREVIEW is, to date, the largest multinational trial to address the prevention of T2D in pre-diabetic adults through diet and exercise intervention. Participants will complete the final intervention in March, 2018.
KW - Journal Article
U2 - 10.3390/nu9060632
DO - 10.3390/nu9060632
M3 - Journal article
C2 - 28632180
SN - 2072-6643
VL - 9
JO - Nutrients
JF - Nutrients
IS - 6
M1 - 632
ER -
