TY - JOUR
T1 - Prevalence of cervical, oral, and anal human papillomavirus infection in women living with HIV in Denmark – The SHADE cohort study
AU - Thorsteinsson, Kristina
AU - Storgaard, Merete
AU - Katzenstein, Terese L.
AU - Ladelund, Steen
AU - Rönsholt, Frederikke F.
AU - Johansen, Isik Somuncu
AU - Pedersen, Gitte
AU - Gaardsting, Anne
AU - Nielsen, Lars Nørregård
AU - Bonde, Jesper
AU - Lebech, Anne Mette
PY - 2018
Y1 - 2018
N2 - Background: Women living with HIV (WLWH) have elevated risk of human papillomavirus (HPV) related cancers. Objectives: To assess prevalence, distribution and concordance of cervical, oral, and anal HPV infection, and predictors of oral and anal HPV in WLWH in Denmark. Study design: WLWH followed in the Study on HIV, cervical Abnormalities and infections in women in Denmark (SHADE) were enrolled and examined for cervical, oral, and anal HPV infection. Logistic regression models were used to identify predictors of anal and oral HPV. Results: A total of 214 of 334 WLWH had sufficient DNA for analysis at all three anatomical sites and were included in analyses. Cervical, oral, and anal high-risk (hr) HPV prevalence were 28.0%, 3.7% and 39.3%. Most frequent i) cervical, ii) oral and iii) anal hrHPV genotypes were i) hrHPV58 (8.4%), 52 (5.1%), 16 (5.1%) and 51 (5.1%); ii) 52 (1.4%) and iii) 51 (9.3%), 58 (8.9%), 16 (7.0%) and 18 (7.0%). Among present cervical, oral, and anal hrHPV genotypes, 6.7%, 12.5% and 17.9% were targeted by the 2-or 4-valent HPV vaccines, whereas 50.0%, 50.0% and 42.9% of hrHPV genotypes were covered by the 9-valent HPV vaccine. Anal HPV infection was predicted by cervical HPV infection (adjusted OR 4.47 (95%CI 2.25–8.89)). Conclusion: Cervical and anal HPV infection were highly prevalent in WLWH. Non-16/18 hrHPV genotypes were predominant at all anatomical sites. Almost half of all hrHPV infections at the three anatomical sites could have been prevented by childhood/adolescent vaccination with the 9-valent HPV vaccine.
AB - Background: Women living with HIV (WLWH) have elevated risk of human papillomavirus (HPV) related cancers. Objectives: To assess prevalence, distribution and concordance of cervical, oral, and anal HPV infection, and predictors of oral and anal HPV in WLWH in Denmark. Study design: WLWH followed in the Study on HIV, cervical Abnormalities and infections in women in Denmark (SHADE) were enrolled and examined for cervical, oral, and anal HPV infection. Logistic regression models were used to identify predictors of anal and oral HPV. Results: A total of 214 of 334 WLWH had sufficient DNA for analysis at all three anatomical sites and were included in analyses. Cervical, oral, and anal high-risk (hr) HPV prevalence were 28.0%, 3.7% and 39.3%. Most frequent i) cervical, ii) oral and iii) anal hrHPV genotypes were i) hrHPV58 (8.4%), 52 (5.1%), 16 (5.1%) and 51 (5.1%); ii) 52 (1.4%) and iii) 51 (9.3%), 58 (8.9%), 16 (7.0%) and 18 (7.0%). Among present cervical, oral, and anal hrHPV genotypes, 6.7%, 12.5% and 17.9% were targeted by the 2-or 4-valent HPV vaccines, whereas 50.0%, 50.0% and 42.9% of hrHPV genotypes were covered by the 9-valent HPV vaccine. Anal HPV infection was predicted by cervical HPV infection (adjusted OR 4.47 (95%CI 2.25–8.89)). Conclusion: Cervical and anal HPV infection were highly prevalent in WLWH. Non-16/18 hrHPV genotypes were predominant at all anatomical sites. Almost half of all hrHPV infections at the three anatomical sites could have been prevented by childhood/adolescent vaccination with the 9-valent HPV vaccine.
KW - Cervical cancer, anal cancer
KW - Concordance
KW - Genotype distribution
KW - HPV prevalence
KW - HPV vaccine
KW - Human papillomavirus
KW - Oral cancer
KW - Women living with HIV
U2 - 10.1016/j.jcv.2018.05.010
DO - 10.1016/j.jcv.2018.05.010
M3 - Journal article
C2 - 29906660
AN - SCOPUS:85048307929
SN - 1386-6532
VL - 105
SP - 64
EP - 71
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
ER -
