Pretreatment fasting plasma glucose modifies dietary weight loss maintenance success: Results from a stratified RCT

TY - JOUR

T1 - Pretreatment fasting plasma glucose modifies dietary weight loss maintenance success

T2 - Results from a stratified RCT

AU - Hjorth, Mads Fiil

AU - Due, Anette

AU - Larsen, Thomas Meinert

AU - Astrup, Arne

N1 - CURIS 2017 NEXS 267

PY - 2017/12

Y1 - 2017/12

N2 - Objective: Levels of fasting plasma glucose (FPG) and fasting insulin (FI) were studied as diet-specific prognostic markers for successful weight loss maintenance in participants with overweight. Methods: After losing ≥ 8% of body weight, participants received one of three ad libitum diets for 6 months: (1) a moderate-fat diet high in monounsaturated fatty acids (MUFA); a low-fat, high-fiber diet (Nordic Nutrition Recommendations [NNR]); and the Average Danish Diet (ADD). Participants were categorized as having low (< 90 mg/dL) or high (90-105 mg/dL) FPG based on preintervention values. Median FI among those having high FPG was used as a cutoff for FI (FI ≤ 50 pmol/L; FI > 50 pmol/L). Results: Participants with low FPG and randomized to MUFA, NNR, and ADD regained similarly 2.1 to 2.5 kg after 6 months. By contrast, participants with high FPG and randomized to MUFA, NNR, and ADD regained 2.73 kg (95% CI 1.33 to 4.13; P < 0.001), −0.05 kg (95% CI −1.95 to 1.86; P = 0.96), and 4.16 kg (95% CI 2.27 to 6.06; P < 0.001) after 6 months, respectively, resulting in lower weight regain on NNR compared to ADD (−4.21 kg [95% CI −6.83 to −1.59]; P = 0.002) and MUFA (95% CI −2.77 kg [−5.12 to −0.43]; P = 0.020). The addition of FI strengthened these associations. Conclusions: Slightly elevated pretreatment FPG determined success in dietary weight loss maintenance among overweight patients on ad libitum diets differing in macronutrient and fiber content.

AB - Objective: Levels of fasting plasma glucose (FPG) and fasting insulin (FI) were studied as diet-specific prognostic markers for successful weight loss maintenance in participants with overweight. Methods: After losing ≥ 8% of body weight, participants received one of three ad libitum diets for 6 months: (1) a moderate-fat diet high in monounsaturated fatty acids (MUFA); a low-fat, high-fiber diet (Nordic Nutrition Recommendations [NNR]); and the Average Danish Diet (ADD). Participants were categorized as having low (< 90 mg/dL) or high (90-105 mg/dL) FPG based on preintervention values. Median FI among those having high FPG was used as a cutoff for FI (FI ≤ 50 pmol/L; FI > 50 pmol/L). Results: Participants with low FPG and randomized to MUFA, NNR, and ADD regained similarly 2.1 to 2.5 kg after 6 months. By contrast, participants with high FPG and randomized to MUFA, NNR, and ADD regained 2.73 kg (95% CI 1.33 to 4.13; P < 0.001), −0.05 kg (95% CI −1.95 to 1.86; P = 0.96), and 4.16 kg (95% CI 2.27 to 6.06; P < 0.001) after 6 months, respectively, resulting in lower weight regain on NNR compared to ADD (−4.21 kg [95% CI −6.83 to −1.59]; P = 0.002) and MUFA (95% CI −2.77 kg [−5.12 to −0.43]; P = 0.020). The addition of FI strengthened these associations. Conclusions: Slightly elevated pretreatment FPG determined success in dietary weight loss maintenance among overweight patients on ad libitum diets differing in macronutrient and fiber content.

KW - Journal Article

U2 - 10.1002/oby.22004

DO - 10.1002/oby.22004

M3 - Journal article

C2 - 28985039

SN - 1930-7381

VL - 25

SP - 2045

EP - 2048

JO - Obesity

JF - Obesity

IS - 12

ER -