Presentation of Two Cases with Early Extracranial Metastases from Glioblastoma and Review of the Literature

TY - JOUR

T1 - Presentation of Two Cases with Early Extracranial Metastases from Glioblastoma and Review of the Literature

AU - Johansen, Maria Dinche

AU - Rochat, Per

AU - Law, Ian

AU - Scheie, David

AU - Poulsen, Hans Skovgaard

AU - Muhic, Aida

PY - 2016

Y1 - 2016

N2 - Extracranial metastases from glioblastoma are rare. We report two patients with extracranial metastases from glioblastoma. Case 1 concerns a 59-year-old woman with multiple metastases that spread early in the course of disease. What makes this case unusual is that the tumor had grown into the falx close to the straight sinus and this might be an explanation to the early and extensive metastases. Case 2 presents a 60-year-old man with liver metastasis found at autopsy, and, in this case, it is more difficult to find an explanation. This patient had two spontaneous intracerebral bleeding incidents and extensive bleeding during acute surgery with tumor removal, which might have induced extracranial seeding. The cases presented might have hematogenous spreading in common as an explanation to extracranial metastases from GBM.

AB - Extracranial metastases from glioblastoma are rare. We report two patients with extracranial metastases from glioblastoma. Case 1 concerns a 59-year-old woman with multiple metastases that spread early in the course of disease. What makes this case unusual is that the tumor had grown into the falx close to the straight sinus and this might be an explanation to the early and extensive metastases. Case 2 presents a 60-year-old man with liver metastasis found at autopsy, and, in this case, it is more difficult to find an explanation. This patient had two spontaneous intracerebral bleeding incidents and extensive bleeding during acute surgery with tumor removal, which might have induced extracranial seeding. The cases presented might have hematogenous spreading in common as an explanation to extracranial metastases from GBM.

KW - Journal Article

U2 - 10.1155/2016/8190950

DO - 10.1155/2016/8190950

M3 - Journal article

C2 - 27247816

SN - 2090-6706

VL - 2016

JO - Case Reports in Oncological Medicine

JF - Case Reports in Oncological Medicine

M1 - 8190950

ER -