Preparing and evaluating delivery systems for proteins

L Jorgensen; E H Moeller; M van de Weert; H M Nielsen; S Frokjaer

doi:10.1016/j.ejps.2006.05.008

Preparing and evaluating delivery systems for proteins

L Jorgensen, E H Moeller, M van de Weert, H M Nielsen, S Frokjaer

68 Citationer (Scopus)

Abstract

From a formulation perspective proteins are complex and therefore challenging molecules to develop drug delivery systems for. The success of a formulation depends on the ability of the protein to maintain the native structure and activity during preparation and delivery as well as during shipping and long-term storage of the formulation. Therefore, the development and evaluation of successful and promising drug delivery systems is essential. In the present review, some of the particulate drug delivery systems for parenteral delivery of protein are presented and discussed. The challenge for incorporation of protein in particulate delivery systems is exemplified by water-in-oil emulsions.

Originalsprog	Engelsk
Tidsskrift	European Journal of Pharmaceutical Sciences
Vol/bind	29
Udgave nummer	3-4
Sider (fra-til)	174-82
Antal sider	9
ISSN	0928-0987
DOI	https://doi.org/10.1016/j.ejps.2006.05.008
Status	Udgivet - 2006

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10.1016/j.ejps.2006.05.008

Citationsformater

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title = "Preparing and evaluating delivery systems for proteins",

abstract = "From a formulation perspective proteins are complex and therefore challenging molecules to develop drug delivery systems for. The success of a formulation depends on the ability of the protein to maintain the native structure and activity during preparation and delivery as well as during shipping and long-term storage of the formulation. Therefore, the development and evaluation of successful and promising drug delivery systems is essential. In the present review, some of the particulate drug delivery systems for parenteral delivery of protein are presented and discussed. The challenge for incorporation of protein in particulate delivery systems is exemplified by water-in-oil emulsions.",

keywords = "Calorimetry, Differential Scanning, Drug Delivery Systems, Emulsions, Hydrogels, Liposomes, Microspheres, Nanoparticles, Proteins",

author = "L Jorgensen and Moeller, {E H} and {van de Weert}, M and Nielsen, {H M} and S Frokjaer",

year = "2006",

doi = "10.1016/j.ejps.2006.05.008",

language = "English",

volume = "29",

pages = "174--82",

journal = "European Journal of Pharmaceutical Sciences",

issn = "0928-0987",

publisher = "Elsevier",

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TY - JOUR

T1 - Preparing and evaluating delivery systems for proteins

AU - Jorgensen, L

AU - Moeller, E H

AU - van de Weert, M

AU - Nielsen, H M

AU - Frokjaer, S

PY - 2006

Y1 - 2006

N2 - From a formulation perspective proteins are complex and therefore challenging molecules to develop drug delivery systems for. The success of a formulation depends on the ability of the protein to maintain the native structure and activity during preparation and delivery as well as during shipping and long-term storage of the formulation. Therefore, the development and evaluation of successful and promising drug delivery systems is essential. In the present review, some of the particulate drug delivery systems for parenteral delivery of protein are presented and discussed. The challenge for incorporation of protein in particulate delivery systems is exemplified by water-in-oil emulsions.

AB - From a formulation perspective proteins are complex and therefore challenging molecules to develop drug delivery systems for. The success of a formulation depends on the ability of the protein to maintain the native structure and activity during preparation and delivery as well as during shipping and long-term storage of the formulation. Therefore, the development and evaluation of successful and promising drug delivery systems is essential. In the present review, some of the particulate drug delivery systems for parenteral delivery of protein are presented and discussed. The challenge for incorporation of protein in particulate delivery systems is exemplified by water-in-oil emulsions.

KW - Calorimetry, Differential Scanning

KW - Drug Delivery Systems

KW - Emulsions

KW - Hydrogels

KW - Liposomes

KW - Microspheres

KW - Nanoparticles

KW - Proteins

U2 - 10.1016/j.ejps.2006.05.008

DO - 10.1016/j.ejps.2006.05.008

M3 - Review

C2 - 16828267

SN - 0928-0987

VL - 29

SP - 174

EP - 182

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

IS - 3-4

ER -

Preparing and evaluating delivery systems for proteins

Abstract

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