Preparation of Spirocyclic β-Proline Esters: Geometrically Restricted Building Blocks for Medicinal Chemistry

TY - JOUR

T1 - Preparation of Spirocyclic β-Proline Esters

T2 - Geometrically Restricted Building Blocks for Medicinal Chemistry

AU - Fjelbye, Kasper

AU - Marigo, Mauro

AU - Clausen, Rasmus Prætorius

AU - Juhl, Karsten

PY - 2017

Y1 - 2017

N2 - A series of novel N-Bn-protected spirocyclic β-proline esters were prepared using [3+2] cycloaddition and subsequently converted into their corresponding aldehydes. In addition, two novel N-Cbz-protected spirocyclic β-proline esters were prepared using intramolecular cyclization starting from simple precursors.

AB - A series of novel N-Bn-protected spirocyclic β-proline esters were prepared using [3+2] cycloaddition and subsequently converted into their corresponding aldehydes. In addition, two novel N-Cbz-protected spirocyclic β-proline esters were prepared using intramolecular cyclization starting from simple precursors.

KW - 1,3-dipolar cycloaddition

KW - intramolecular cyclization

KW - oxetanes

KW - spirocycles

KW - β-proline esters

U2 - 10.1055/s-0036-1588902

DO - 10.1055/s-0036-1588902

M3 - Review

AN - SCOPUS:84991735346

SN - 0936-5214

VL - 28

SP - 231

EP - 234

JO - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis

JF - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis

IS - 2

M1 - st-2016-b0534-l

ER -