TY - JOUR
T1 - Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes
T2 - A systematic review and meta-analysis
AU - Lee, Dong-Wook
AU - Kim, Min-Seok
AU - Lim, Youn-Hee
AU - Lee, Nami
AU - Hong, Yun-Chul
N1 - Copyright © 2018 Elsevier Inc. All rights reserved.
PY - 2018/11
Y1 - 2018/11
N2 - BACKGROUND: Di-(2-ethylhexyl) phthalate (DEHP), the most widely used phthalate, has recently been associated with neurodevelopmental disturbances in children. However, the risk is yet to be quantified. Therefore, a systematic review and meta-analysis focusing on the association between exposure to DEHP and neurodevelopmental outcomes is necessary, with particular attention to study design (longitudinal vs. cross-sectional).METHODS: We performed a comprehensive literature search for associations between exposure to DEHP and neurodevelopmental outcomes. Among 106 published studies found in public databases, eight longitudinal studies and two cross-sectional studies were included in the meta-analysis.RESULTS: We observed a statistically significant association between the concentrations of DEHP metabolites and the neurodevelopment outcomes of children among cross-sectional results, and found significant association between DEHP exposure measured in prenatal period and the psychomotor development outcomes measured later in childhood.CONCLUSIONS: To our knowledge, this is the first meta-analysis of studies investigating the association between DEHP exposure and neurodevelopment in children. A need exists for more researches and a precautionary policy for potential health hazard of DEHP, the most commonly used phthalate, to promote healthier neurodevelopment in children.
AB - BACKGROUND: Di-(2-ethylhexyl) phthalate (DEHP), the most widely used phthalate, has recently been associated with neurodevelopmental disturbances in children. However, the risk is yet to be quantified. Therefore, a systematic review and meta-analysis focusing on the association between exposure to DEHP and neurodevelopmental outcomes is necessary, with particular attention to study design (longitudinal vs. cross-sectional).METHODS: We performed a comprehensive literature search for associations between exposure to DEHP and neurodevelopmental outcomes. Among 106 published studies found in public databases, eight longitudinal studies and two cross-sectional studies were included in the meta-analysis.RESULTS: We observed a statistically significant association between the concentrations of DEHP metabolites and the neurodevelopment outcomes of children among cross-sectional results, and found significant association between DEHP exposure measured in prenatal period and the psychomotor development outcomes measured later in childhood.CONCLUSIONS: To our knowledge, this is the first meta-analysis of studies investigating the association between DEHP exposure and neurodevelopment in children. A need exists for more researches and a precautionary policy for potential health hazard of DEHP, the most commonly used phthalate, to promote healthier neurodevelopment in children.
KW - Child
KW - Child Development
KW - Cross-Sectional Studies
KW - Diethylhexyl Phthalate/adverse effects
KW - Female
KW - Humans
KW - Longitudinal Studies
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects/epidemiology
KW - Psychomotor Disorders/epidemiology
U2 - 10.1016/j.envres.2018.08.023
DO - 10.1016/j.envres.2018.08.023
M3 - Journal article
C2 - 30145432
SN - 0013-9351
VL - 167
SP - 558
EP - 566
JO - Environmental Research
JF - Environmental Research
ER -