Pregnancy-Induced Changes in Systemic Gene Expression among Healthy Women and Women with Rheumatoid Arthritis

Anuradha Mittal; Lior Pachter; J. Lee Nelson; Hanne Kjærgaard; Mette Kiel Smed; Virginia L. Gildengorin; Vibeke Zoffmann; Merete Lund Hetland; Nicholas P. Jewell; Jorn Olsen; Damini Jawaheer

doi:10.1371/journal.pone.0145204

Pregnancy-Induced Changes in Systemic Gene Expression among Healthy Women and Women with Rheumatoid Arthritis

Anuradha Mittal, Lior Pachter, J. Lee Nelson, Hanne Kjærgaard, Mette Kiel Smed, Virginia L. Gildengorin, Vibeke Zoffmann, Merete Lund Hetland, Nicholas P. Jewell, Jorn Olsen, Damini Jawaheer

Institut for Klinisk Medicin

9 Citationer (Scopus)

Abstract

Background Pregnancy induces drastic biological changes systemically, and has a beneficial effect on some autoimmune conditions such as rheumatoid arthritis (RA). However, specific systemic changes that occur as a result of pregnancy have not been thoroughly examined in healthy women or women with RA. The goal of this study was to identify genes with expression patterns associated with pregnancy, compared to pre-pregnancy as baseline and determine whether those associations are modified by presence of RA. Results In our RNA sequencing (RNA-seq) dataset from 5 healthy women and 20 women with RA, normalized expression levels of 4,710 genes were significantly associated with pregnancy status (pre-pregnancy, first, second and third trimesters) over time, irrespective of presence of RA (False Discovery Rate (FDR)-Adjusted p value

Originalsprog	Engelsk
Artikelnummer	e0145204
Tidsskrift	PLOS ONE
Vol/bind	10
Udgave nummer	12
Sider (fra-til)	1-15
Antal sider	15
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0145204
Status	Udgivet - 18 dec. 2015

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abstract = "Background Pregnancy induces drastic biological changes systemically, and has a beneficial effect on some autoimmune conditions such as rheumatoid arthritis (RA). However, specific systemic changes that occur as a result of pregnancy have not been thoroughly examined in healthy women or women with RA. The goal of this study was to identify genes with expression patterns associated with pregnancy, compared to pre-pregnancy as baseline and determine whether those associations are modified by presence of RA. Results In our RNA sequencing (RNA-seq) dataset from 5 healthy women and 20 women with RA, normalized expression levels of 4,710 genes were significantly associated with pregnancy status (pre-pregnancy, first, second and third trimesters) over time, irrespective of presence of RA (False Discovery Rate (FDR)-Adjusted p value",

author = "Anuradha Mittal and Lior Pachter and Nelson, {J. Lee} and Hanne Kj{\ae}rgaard and Smed, {Mette Kiel} and Gildengorin, {Virginia L.} and Vibeke Zoffmann and Hetland, {Merete Lund} and Jewell, {Nicholas P.} and Jorn Olsen and Damini Jawaheer",

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AU - Mittal, Anuradha

AU - Pachter, Lior

AU - Nelson, J. Lee

AU - Kjærgaard, Hanne

AU - Smed, Mette Kiel

AU - Gildengorin, Virginia L.

AU - Zoffmann, Vibeke

AU - Hetland, Merete Lund

AU - Jewell, Nicholas P.

AU - Olsen, Jorn

AU - Jawaheer, Damini

PY - 2015/12/18

Y1 - 2015/12/18

N2 - Background Pregnancy induces drastic biological changes systemically, and has a beneficial effect on some autoimmune conditions such as rheumatoid arthritis (RA). However, specific systemic changes that occur as a result of pregnancy have not been thoroughly examined in healthy women or women with RA. The goal of this study was to identify genes with expression patterns associated with pregnancy, compared to pre-pregnancy as baseline and determine whether those associations are modified by presence of RA. Results In our RNA sequencing (RNA-seq) dataset from 5 healthy women and 20 women with RA, normalized expression levels of 4,710 genes were significantly associated with pregnancy status (pre-pregnancy, first, second and third trimesters) over time, irrespective of presence of RA (False Discovery Rate (FDR)-Adjusted p value

AB - Background Pregnancy induces drastic biological changes systemically, and has a beneficial effect on some autoimmune conditions such as rheumatoid arthritis (RA). However, specific systemic changes that occur as a result of pregnancy have not been thoroughly examined in healthy women or women with RA. The goal of this study was to identify genes with expression patterns associated with pregnancy, compared to pre-pregnancy as baseline and determine whether those associations are modified by presence of RA. Results In our RNA sequencing (RNA-seq) dataset from 5 healthy women and 20 women with RA, normalized expression levels of 4,710 genes were significantly associated with pregnancy status (pre-pregnancy, first, second and third trimesters) over time, irrespective of presence of RA (False Discovery Rate (FDR)-Adjusted p value

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Pregnancy-Induced Changes in Systemic Gene Expression among Healthy Women and Women with Rheumatoid Arthritis

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