Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet

Thea Toft Hansen; Mads Fiil Hjorth; Karoline Sandby; Sarah Vold Andersen; Arne Astrup; Christian Ritz; Mònica Bulló; Maria Lucia Camacho-Barcía; Jesús Francisco García-Gavilán; Jordi Salas-Salvadó; Joanne A Harrold; Jason C G Halford; Anders Mikael Sjödin

doi:10.1017/s0007114519001296

Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet

Thea Toft Hansen, Mads Fiil Hjorth, Karoline Sandby, Sarah Vold Andersen, Arne Astrup, Christian Ritz, Mònica Bulló, Maria Lucia Camacho-Barcía, Jesús Francisco García-Gavilán, Jordi Salas-Salvadó, Joanne A Harrold, Jason C G Halford, Anders Mikael Sjödin

8 Citationer (Scopus)

Abstract

A low-energy diet (LED) is an effective approach to induce a rapid weight loss in individuals with overweight. However, reported disproportionally large losses of fat-free mass (FFM) after an LED trigger the question of adequate protein content. Additionally, not all individuals have the same degree of weight loss success. After an 8-week LED providing 5020 kJ/d for men and 4184 kJ/d for women (84/70 g protein/d) among overweight and obese adults, we aimed to investigate the relationship between protein intake relative to initial FFM and proportion of weight lost as FFM as well as the individual characteristics associated with weight loss success. We assessed all outcomes baseline and after the LED. A total of 286 participants (sixty-four men and 222 women) initiated the LED of which 82 % completed and 70 % achieved a substantial weight loss (defined as ≥8 %). Protein intake in the range 1·0-1·6 g protein/d per kg FFM at baseline for men and 1·1-2·2 g protein/d per kg FFM at baseline for women was not associated with loss of FFM (P = 0·632). Higher Three-Factor Eating Questionnaire (TFEQ) hunger at baseline and reductions in TFEQ disinhibition and hunger during the LED were associated with larger weight loss (all P ≤ 0·020); whereas lower sleep quality at baseline predicted less successful weight loss using intention to treat analysis (P = 0·021), possibly driven by those dropping out (n 81, P = 0·067 v. completers: n 198, P = 0·659). Thus, the protein intakes relative to initial FFM were sufficient for maintenance of FFM and specific eating behaviour characteristics were associated with weight loss success.

Originalsprog	Engelsk
Tidsskrift	British Journal of Nutrition
Vol/bind	122
Udgave nummer	4
Sider (fra-til)	468-479
Antal sider	12
ISSN	0007-1145
DOI	https://doi.org/10.1017/s0007114519001296
Status	Udgivet - 28 aug. 2019

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10.1017/s0007114519001296

div-class-title-predictors-of-successful-weight-loss-with-relative-maintenance-of-fat-free-mass-in-individuals-with-overweight-and-obesity-on-an-8-week-low-energy-diet-div.pdfForlagets udgivne version, 1,34 MB

Citationsformater

Hansen, T. T., Hjorth, M. F., Sandby, K., Andersen, S. V., Astrup, A., Ritz, C., Bulló, M., Camacho-Barcía, M. L., García-Gavilán, J. F., Salas-Salvadó, J., Harrold, J. A., Halford, J. C. G., & Sjödin, A. M. (2019). Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet. British Journal of Nutrition, 122(4), 468-479. https://doi.org/10.1017/s0007114519001296

Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet. / Hansen, Thea Toft; Hjorth, Mads Fiil; Sandby, Karoline et al.

I: British Journal of Nutrition, Bind 122, Nr. 4, 28.08.2019, s. 468-479.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Hansen, TT, Hjorth, MF, Sandby, K, Andersen, SV, Astrup, A, Ritz, C, Bulló, M, Camacho-Barcía, ML, García-Gavilán, JF, Salas-Salvadó, J, Harrold, JA, Halford, JCG & Sjödin, AM 2019, 'Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet', British Journal of Nutrition, bind 122, nr. 4, s. 468-479. https://doi.org/10.1017/s0007114519001296

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abstract = "A low-energy diet (LED) is an effective approach to induce a rapid weight loss in individuals with overweight. However, reported disproportionally large losses of fat-free mass (FFM) after an LED trigger the question of adequate protein content. Additionally, not all individuals have the same degree of weight loss success. After an 8-week LED providing 5020 kJ/d for men and 4184 kJ/d for women (84/70 g protein/d) among overweight and obese adults, we aimed to investigate the relationship between protein intake relative to initial FFM and proportion of weight lost as FFM as well as the individual characteristics associated with weight loss success. We assessed all outcomes baseline and after the LED. A total of 286 participants (sixty-four men and 222 women) initiated the LED of which 82 % completed and 70 % achieved a substantial weight loss (defined as ≥8 %). Protein intake in the range 1·0-1·6 g protein/d per kg FFM at baseline for men and 1·1-2·2 g protein/d per kg FFM at baseline for women was not associated with loss of FFM (P = 0·632). Higher Three-Factor Eating Questionnaire (TFEQ) hunger at baseline and reductions in TFEQ disinhibition and hunger during the LED were associated with larger weight loss (all P ≤ 0·020); whereas lower sleep quality at baseline predicted less successful weight loss using intention to treat analysis (P = 0·021), possibly driven by those dropping out (n 81, P = 0·067 v. completers: n 198, P = 0·659). Thus, the protein intakes relative to initial FFM were sufficient for maintenance of FFM and specific eating behaviour characteristics were associated with weight loss success.",

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AU - Hansen, Thea Toft

AU - Hjorth, Mads Fiil

AU - Sandby, Karoline

AU - Andersen, Sarah Vold

AU - Astrup, Arne

AU - Ritz, Christian

AU - Bulló, Mònica

AU - Camacho-Barcía, Maria Lucia

AU - García-Gavilán, Jesús Francisco

AU - Salas-Salvadó, Jordi

AU - Harrold, Joanne A

AU - Halford, Jason C G

AU - Sjödin, Anders Mikael

N1 - CURIS 2019 NEXS 224

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N2 - A low-energy diet (LED) is an effective approach to induce a rapid weight loss in individuals with overweight. However, reported disproportionally large losses of fat-free mass (FFM) after an LED trigger the question of adequate protein content. Additionally, not all individuals have the same degree of weight loss success. After an 8-week LED providing 5020 kJ/d for men and 4184 kJ/d for women (84/70 g protein/d) among overweight and obese adults, we aimed to investigate the relationship between protein intake relative to initial FFM and proportion of weight lost as FFM as well as the individual characteristics associated with weight loss success. We assessed all outcomes baseline and after the LED. A total of 286 participants (sixty-four men and 222 women) initiated the LED of which 82 % completed and 70 % achieved a substantial weight loss (defined as ≥8 %). Protein intake in the range 1·0-1·6 g protein/d per kg FFM at baseline for men and 1·1-2·2 g protein/d per kg FFM at baseline for women was not associated with loss of FFM (P = 0·632). Higher Three-Factor Eating Questionnaire (TFEQ) hunger at baseline and reductions in TFEQ disinhibition and hunger during the LED were associated with larger weight loss (all P ≤ 0·020); whereas lower sleep quality at baseline predicted less successful weight loss using intention to treat analysis (P = 0·021), possibly driven by those dropping out (n 81, P = 0·067 v. completers: n 198, P = 0·659). Thus, the protein intakes relative to initial FFM were sufficient for maintenance of FFM and specific eating behaviour characteristics were associated with weight loss success.

AB - A low-energy diet (LED) is an effective approach to induce a rapid weight loss in individuals with overweight. However, reported disproportionally large losses of fat-free mass (FFM) after an LED trigger the question of adequate protein content. Additionally, not all individuals have the same degree of weight loss success. After an 8-week LED providing 5020 kJ/d for men and 4184 kJ/d for women (84/70 g protein/d) among overweight and obese adults, we aimed to investigate the relationship between protein intake relative to initial FFM and proportion of weight lost as FFM as well as the individual characteristics associated with weight loss success. We assessed all outcomes baseline and after the LED. A total of 286 participants (sixty-four men and 222 women) initiated the LED of which 82 % completed and 70 % achieved a substantial weight loss (defined as ≥8 %). Protein intake in the range 1·0-1·6 g protein/d per kg FFM at baseline for men and 1·1-2·2 g protein/d per kg FFM at baseline for women was not associated with loss of FFM (P = 0·632). Higher Three-Factor Eating Questionnaire (TFEQ) hunger at baseline and reductions in TFEQ disinhibition and hunger during the LED were associated with larger weight loss (all P ≤ 0·020); whereas lower sleep quality at baseline predicted less successful weight loss using intention to treat analysis (P = 0·021), possibly driven by those dropping out (n 81, P = 0·067 v. completers: n 198, P = 0·659). Thus, the protein intakes relative to initial FFM were sufficient for maintenance of FFM and specific eating behaviour characteristics were associated with weight loss success.

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KW - Appetite

KW - Hunger

KW - Behaviour

KW - Protein

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DO - 10.1017/s0007114519001296

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EP - 479

JO - British Journal of Nutrition

JF - British Journal of Nutrition

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ER -

Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet

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