Predictive value of the corrected TIMI frame count in patients with suspected angina pectoris but no obstructive coronary artery disease at angiography

Lasse Jespersen; Steen Z Abildstrøm; Adam Peña; Peter R Hansen; Eva Prescott

doi:10.1007/s00392-014-0665-7

Predictive value of the corrected TIMI frame count in patients with suspected angina pectoris but no obstructive coronary artery disease at angiography

Lasse Jespersen, Steen Z Abildstrøm, Adam Peña, Peter R Hansen, Eva Prescott

Institut for Klinisk Medicin

3 Citationer (Scopus)

Abstract

AIMS: To evaluate whether the corrected thrombolysis in myocardial infarction frame count (CTFC), an index of resting coronary blood flow, is associated with the risk of major adverse cardiovascular events (MACE) in patients with suspected stable angina pectoris (SAP) but no obstructive coronary artery disease (CAD) at angiography.

METHODS AND RESULTS: In this case-control study, CTFC at baseline in 127 patients (50 % women) who subsequently experienced a myocardial infarction, non-hemorrhagic stroke or cardiovascular death during 2001-2011 was compared with CTFC in 254 event-free matched controls. All patients had suspected SAP but no obstructive (≥50 % stenosis) CAD at baseline angiography. Mean CTFC in controls was 23.4 (95 % confidence interval 20.9-25.9) frames and mean CTFC in cases did not differ significantly with a difference of -1.0 (-3.1 to 1.1) frames (P = 0.35) and no sex-specific interaction (P = 0.18). In a conditional logistic regression model, we found no dose-response relationship between CTFC and the risk of MACE, i.e., compared to the risk in the lowest CTFC quintile, the odds ratios for MACE were 1.3 (0.7-2.6), 0.7 (0.3-1.3), 0.7 (0.4-1.5) and 1.0 (0.5-2.1) in the second, third, fourth and fifth CTFC quintiles, respectively. Adjustment for cardiac risk factors including diabetes, active smoking, body mass index, and use of lipid-lowering and antihypertensive medication did not significantly change the results.

CONCLUSIONS: In patients with SAP symptoms without obstructive CAD at angiography, CTFC is not associated with the risk of MACE.

Originalsprog	Engelsk
Tidsskrift	Clinical Research in Cardiology
Vol/bind	103
Udgave nummer	5
Sider (fra-til)	381-387
Antal sider	7
ISSN	1861-0684
DOI	https://doi.org/10.1007/s00392-014-0665-7
Status	Udgivet - maj 2014

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10.1007/s00392-014-0665-7

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Predictive value of the corrected TIMI frame count in patients with suspected angina pectoris but no obstructive coronary artery disease at angiography. / Jespersen, Lasse; Abildstrøm, Steen Z; Peña, Adam et al.

I: Clinical Research in Cardiology, Bind 103, Nr. 5, 05.2014, s. 381-387.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

@article{5b3b04dc00464492bcb9860816f86e91,

title = "Predictive value of the corrected TIMI frame count in patients with suspected angina pectoris but no obstructive coronary artery disease at angiography",

abstract = "AIMS: To evaluate whether the corrected thrombolysis in myocardial infarction frame count (CTFC), an index of resting coronary blood flow, is associated with the risk of major adverse cardiovascular events (MACE) in patients with suspected stable angina pectoris (SAP) but no obstructive coronary artery disease (CAD) at angiography.METHODS AND RESULTS: In this case-control study, CTFC at baseline in 127 patients (50 % women) who subsequently experienced a myocardial infarction, non-hemorrhagic stroke or cardiovascular death during 2001-2011 was compared with CTFC in 254 event-free matched controls. All patients had suspected SAP but no obstructive (≥50 % stenosis) CAD at baseline angiography. Mean CTFC in controls was 23.4 (95 % confidence interval 20.9-25.9) frames and mean CTFC in cases did not differ significantly with a difference of -1.0 (-3.1 to 1.1) frames (P = 0.35) and no sex-specific interaction (P = 0.18). In a conditional logistic regression model, we found no dose-response relationship between CTFC and the risk of MACE, i.e., compared to the risk in the lowest CTFC quintile, the odds ratios for MACE were 1.3 (0.7-2.6), 0.7 (0.3-1.3), 0.7 (0.4-1.5) and 1.0 (0.5-2.1) in the second, third, fourth and fifth CTFC quintiles, respectively. Adjustment for cardiac risk factors including diabetes, active smoking, body mass index, and use of lipid-lowering and antihypertensive medication did not significantly change the results.CONCLUSIONS: In patients with SAP symptoms without obstructive CAD at angiography, CTFC is not associated with the risk of MACE.",

keywords = "Aged, Angina Pectoris, Blood Flow Velocity, Case-Control Studies, Comorbidity, Confidence Intervals, Coronary Angiography, Coronary Circulation, Coronary Thrombosis, Denmark, Diagnosis, Differential, Female, Humans, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Myocardial Infarction, Predictive Value of Tests, Regional Blood Flow, Retrospective Studies, Risk Assessment, Survival Rate, Thrombolytic Therapy, Vascular Patency",

author = "Lasse Jespersen and Abildstr{\o}m, {Steen Z} and Adam Pe{\~n}a and Hansen, {Peter R} and Eva Prescott",

year = "2014",

month = may,

doi = "10.1007/s00392-014-0665-7",

language = "English",

volume = "103",

pages = "381--387",

journal = "Clinical Research in Cardiology",

issn = "1861-0684",

publisher = "Springer Medizin",

number = "5",

}

TY - JOUR

T1 - Predictive value of the corrected TIMI frame count in patients with suspected angina pectoris but no obstructive coronary artery disease at angiography

AU - Jespersen, Lasse

AU - Abildstrøm, Steen Z

AU - Peña, Adam

AU - Hansen, Peter R

AU - Prescott, Eva

PY - 2014/5

Y1 - 2014/5

N2 - AIMS: To evaluate whether the corrected thrombolysis in myocardial infarction frame count (CTFC), an index of resting coronary blood flow, is associated with the risk of major adverse cardiovascular events (MACE) in patients with suspected stable angina pectoris (SAP) but no obstructive coronary artery disease (CAD) at angiography.METHODS AND RESULTS: In this case-control study, CTFC at baseline in 127 patients (50 % women) who subsequently experienced a myocardial infarction, non-hemorrhagic stroke or cardiovascular death during 2001-2011 was compared with CTFC in 254 event-free matched controls. All patients had suspected SAP but no obstructive (≥50 % stenosis) CAD at baseline angiography. Mean CTFC in controls was 23.4 (95 % confidence interval 20.9-25.9) frames and mean CTFC in cases did not differ significantly with a difference of -1.0 (-3.1 to 1.1) frames (P = 0.35) and no sex-specific interaction (P = 0.18). In a conditional logistic regression model, we found no dose-response relationship between CTFC and the risk of MACE, i.e., compared to the risk in the lowest CTFC quintile, the odds ratios for MACE were 1.3 (0.7-2.6), 0.7 (0.3-1.3), 0.7 (0.4-1.5) and 1.0 (0.5-2.1) in the second, third, fourth and fifth CTFC quintiles, respectively. Adjustment for cardiac risk factors including diabetes, active smoking, body mass index, and use of lipid-lowering and antihypertensive medication did not significantly change the results.CONCLUSIONS: In patients with SAP symptoms without obstructive CAD at angiography, CTFC is not associated with the risk of MACE.

AB - AIMS: To evaluate whether the corrected thrombolysis in myocardial infarction frame count (CTFC), an index of resting coronary blood flow, is associated with the risk of major adverse cardiovascular events (MACE) in patients with suspected stable angina pectoris (SAP) but no obstructive coronary artery disease (CAD) at angiography.METHODS AND RESULTS: In this case-control study, CTFC at baseline in 127 patients (50 % women) who subsequently experienced a myocardial infarction, non-hemorrhagic stroke or cardiovascular death during 2001-2011 was compared with CTFC in 254 event-free matched controls. All patients had suspected SAP but no obstructive (≥50 % stenosis) CAD at baseline angiography. Mean CTFC in controls was 23.4 (95 % confidence interval 20.9-25.9) frames and mean CTFC in cases did not differ significantly with a difference of -1.0 (-3.1 to 1.1) frames (P = 0.35) and no sex-specific interaction (P = 0.18). In a conditional logistic regression model, we found no dose-response relationship between CTFC and the risk of MACE, i.e., compared to the risk in the lowest CTFC quintile, the odds ratios for MACE were 1.3 (0.7-2.6), 0.7 (0.3-1.3), 0.7 (0.4-1.5) and 1.0 (0.5-2.1) in the second, third, fourth and fifth CTFC quintiles, respectively. Adjustment for cardiac risk factors including diabetes, active smoking, body mass index, and use of lipid-lowering and antihypertensive medication did not significantly change the results.CONCLUSIONS: In patients with SAP symptoms without obstructive CAD at angiography, CTFC is not associated with the risk of MACE.

KW - Aged

KW - Angina Pectoris

KW - Blood Flow Velocity

KW - Case-Control Studies

KW - Comorbidity

KW - Confidence Intervals

KW - Coronary Angiography

KW - Coronary Circulation

KW - Coronary Thrombosis

KW - Denmark

KW - Diagnosis, Differential

KW - Female

KW - Humans

KW - Kaplan-Meier Estimate

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Predictive Value of Tests

KW - Regional Blood Flow

KW - Retrospective Studies

KW - Risk Assessment

KW - Survival Rate

KW - Thrombolytic Therapy

KW - Vascular Patency

U2 - 10.1007/s00392-014-0665-7

DO - 10.1007/s00392-014-0665-7

M3 - Journal article

C2 - 24442337

SN - 1861-0684

VL - 103

SP - 381

EP - 387

JO - Clinical Research in Cardiology

JF - Clinical Research in Cardiology

IS - 5

ER -

Predictive value of the corrected TIMI frame count in patients with suspected angina pectoris but no obstructive coronary artery disease at angiography

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