Prediction of allergenicity of gene-modified foods by serum-based testing

TY - JOUR

T1 - Prediction of allergenicity of gene-modified foods by serum-based testing

AU - Poulsen, Lars K.

PY - 2002/5

Y1 - 2002/5

N2 - On the basis of applying the IFBC/ILSI decision tree in a number of cases, a refinement of the scheme is suggested. Large differences in allergenic potential may be obtained by altering the route of administration of an allergen. Because an inhalation allergen can induce symptoms at different threshold doses depending on whether it is introduced via the inhalation or oral route, we propose that double-blind, placebo-controlled food challenges be performed in all cases of inhalation allergens being present in foods. Even proteins never previously ingested may cause IgE binding and elicit clinically relevant symptoms.

AB - On the basis of applying the IFBC/ILSI decision tree in a number of cases, a refinement of the scheme is suggested. Large differences in allergenic potential may be obtained by altering the route of administration of an allergen. Because an inhalation allergen can induce symptoms at different threshold doses depending on whether it is introduced via the inhalation or oral route, we propose that double-blind, placebo-controlled food challenges be performed in all cases of inhalation allergens being present in foods. Even proteins never previously ingested may cause IgE binding and elicit clinically relevant symptoms.

KW - Allergens

KW - Crops, Agricultural

KW - Food Hypersensitivity

KW - Humans

KW - Immunoglobulin E

KW - Placebos

KW - Plants, Genetically Modified

KW - Risk Factors

M3 - Journal article

C2 - 12023205

SN - 0077-8923

VL - 964

SP - 185

EP - 196

JO - Annals of The Lyceum of Natural History of New York

JF - Annals of The Lyceum of Natural History of New York

ER -