PRDM proteins: Important players in differentiation and disease

Cathrine Kolster Fog Tonnesen; Giorgio G Galli; Anders H Lund

doi:10.1002/bies.201100107

PRDM proteins: Important players in differentiation and disease

Cathrine Kolster Fog Tonnesen, Giorgio G Galli, Anders H Lund

126 Citationer (Scopus)

Abstract

The PRDM family has recently spawned considerable interest as it has been implicated in fundamental aspects of cellular differentiation and exhibits expanding ties to human diseases. The PRDMs belong to the SET domain family of histone methyltransferases, however, enzymatic activity has been determined for only few PRDMs suggesting that they act by recruiting co-factors or, more speculatively, confer methylation of non-histone targets. Several PRDM family members are deregulated in human diseases, most prominently in hematological malignancies and solid cancers, where they can act as both tumor suppressors or drivers of oncogenic processes. The molecular mechanisms have been delineated for only few PRDMs and little is known about functional redundancy within the family. Future studies should identify target genes of PRDM proteins and the protein complexes in which PRDM proteins reside to provide a more comprehensive understanding of the biological and biochemical functions of this important protein family.

Originalsprog	Engelsk
Tidsskrift	BioEssays
ISSN	0265-9247
DOI	https://doi.org/10.1002/bies.201100107
Status	Udgivet - jan. 2012

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10.1002/bies.201100107

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title = "PRDM proteins: Important players in differentiation and disease",

abstract = "The PRDM family has recently spawned considerable interest as it has been implicated in fundamental aspects of cellular differentiation and exhibits expanding ties to human diseases. The PRDMs belong to the SET domain family of histone methyltransferases, however, enzymatic activity has been determined for only few PRDMs suggesting that they act by recruiting co-factors or, more speculatively, confer methylation of non-histone targets. Several PRDM family members are deregulated in human diseases, most prominently in hematological malignancies and solid cancers, where they can act as both tumor suppressors or drivers of oncogenic processes. The molecular mechanisms have been delineated for only few PRDMs and little is known about functional redundancy within the family. Future studies should identify target genes of PRDM proteins and the protein complexes in which PRDM proteins reside to provide a more comprehensive understanding of the biological and biochemical functions of this important protein family.",

author = "Tonnesen, {Cathrine Kolster Fog} and Galli, {Giorgio G} and Lund, {Anders H}",

note = "Copyright {\textcopyright} 2011 WILEY Periodicals, Inc.",

year = "2012",

month = jan,

doi = "10.1002/bies.201100107",

language = "English",

journal = "BioEssays",

issn = "0265-9247",

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T1 - PRDM proteins: Important players in differentiation and disease

AU - Tonnesen, Cathrine Kolster Fog

AU - Galli, Giorgio G

AU - Lund, Anders H

PY - 2012/1

Y1 - 2012/1

N2 - The PRDM family has recently spawned considerable interest as it has been implicated in fundamental aspects of cellular differentiation and exhibits expanding ties to human diseases. The PRDMs belong to the SET domain family of histone methyltransferases, however, enzymatic activity has been determined for only few PRDMs suggesting that they act by recruiting co-factors or, more speculatively, confer methylation of non-histone targets. Several PRDM family members are deregulated in human diseases, most prominently in hematological malignancies and solid cancers, where they can act as both tumor suppressors or drivers of oncogenic processes. The molecular mechanisms have been delineated for only few PRDMs and little is known about functional redundancy within the family. Future studies should identify target genes of PRDM proteins and the protein complexes in which PRDM proteins reside to provide a more comprehensive understanding of the biological and biochemical functions of this important protein family.

AB - The PRDM family has recently spawned considerable interest as it has been implicated in fundamental aspects of cellular differentiation and exhibits expanding ties to human diseases. The PRDMs belong to the SET domain family of histone methyltransferases, however, enzymatic activity has been determined for only few PRDMs suggesting that they act by recruiting co-factors or, more speculatively, confer methylation of non-histone targets. Several PRDM family members are deregulated in human diseases, most prominently in hematological malignancies and solid cancers, where they can act as both tumor suppressors or drivers of oncogenic processes. The molecular mechanisms have been delineated for only few PRDMs and little is known about functional redundancy within the family. Future studies should identify target genes of PRDM proteins and the protein complexes in which PRDM proteins reside to provide a more comprehensive understanding of the biological and biochemical functions of this important protein family.

U2 - 10.1002/bies.201100107

DO - 10.1002/bies.201100107

M3 - Journal article

C2 - 22028065

SN - 0265-9247

JO - BioEssays

JF - BioEssays

ER -

PRDM proteins: Important players in differentiation and disease

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