Positronemissionstomografi. En ny målemetode til billedmaessig fremstilling af regionale fysiologiske og biokemiske parametre

TY - JOUR

T1 - Positronemissionstomografi. En ny målemetode til billedmaessig fremstilling af regionale fysiologiske og biokemiske parametre

AU - Bolwig, T G

AU - Haunsø, S

AU - Hove, J D

AU - Hesse, B

AU - Højgaard, L

AU - Jensen, M

AU - Paulson, O B

AU - Svendsen, Jesper Hastrup

AU - Sørensen, S S

PY - 1994/10/24

Y1 - 1994/10/24

N2 - Positron emission tomography (PET) is a method for quantitative imaging of regional physiological and biochemical parameters. Positron emitting radioactive isotopes can be produced by a cyclotron, eg. the biologically important carbon (11C), oxygen (15O), and nitrogen (13N) elements. With the tomographic principle of the PET scanner the quantitative distribution of the administered isotopes can be determined and images can be provided as well as dynamic information on blood flow, metabolism and receptor function. In neurology PET has been used for investigations on numerous physiological processes in the brain: circulation, metabolism and receptor studies. In Parkinson's disease PET studies have been able to localize the pathology specifically, and in early stroke PET technique can outline focal areas with living but non-functioning cells, and this could make it possible to intervene in this early state. With positron emission tomography a quantitative evaluation of myocardial blood flow, glucose and fatty acid metabolism can be made as well as combined assessments of blood flow and metabolism. Combined studies of blood flow and metabolism can determine whether myocardial segments with abnormal motility consist of necrotic or viable tissue, thereby delineating effects of revascularisation. In the future it will probably be possible to characterize the myocardial receptor status in different cardiac diseases. The PET technique is used in oncology for clinical as well as more basic research on tumor perfusion and metabolism. Further, tumor uptake of positron labelled cytotoxic drugs might predict the clinical benefit of treatment.

AB - Positron emission tomography (PET) is a method for quantitative imaging of regional physiological and biochemical parameters. Positron emitting radioactive isotopes can be produced by a cyclotron, eg. the biologically important carbon (11C), oxygen (15O), and nitrogen (13N) elements. With the tomographic principle of the PET scanner the quantitative distribution of the administered isotopes can be determined and images can be provided as well as dynamic information on blood flow, metabolism and receptor function. In neurology PET has been used for investigations on numerous physiological processes in the brain: circulation, metabolism and receptor studies. In Parkinson's disease PET studies have been able to localize the pathology specifically, and in early stroke PET technique can outline focal areas with living but non-functioning cells, and this could make it possible to intervene in this early state. With positron emission tomography a quantitative evaluation of myocardial blood flow, glucose and fatty acid metabolism can be made as well as combined assessments of blood flow and metabolism. Combined studies of blood flow and metabolism can determine whether myocardial segments with abnormal motility consist of necrotic or viable tissue, thereby delineating effects of revascularisation. In the future it will probably be possible to characterize the myocardial receptor status in different cardiac diseases. The PET technique is used in oncology for clinical as well as more basic research on tumor perfusion and metabolism. Further, tumor uptake of positron labelled cytotoxic drugs might predict the clinical benefit of treatment.

KW - Brain

KW - Cerebrovascular Disorders

KW - Heart

KW - Humans

KW - Myocardium

KW - Neoplasms

KW - Parkinson Disease

KW - Schizophrenia

KW - Tomography, Emission-Computed

M3 - Tidsskriftartikel

C2 - 7810006

SN - 0041-5782

VL - 156

SP - 6341

EP - 6347

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 43

ER -