Positioning Europe for the EPITRANSCRIPTOMICS challenge

Michael F Jantsch; Alessandro Quattrone; Mary O'Connell; Mark Helm; Michaela Frye; Manuel Macias-Gonzales; Marie Ohman; Stefan Ameres; Luc Willems; Francois Fuks; Anastasis Oulas; Stepanka Vanacova; Henrik Nielsen; Cecile Bousquet-Antonelli; Yuri Motorin; Jean-Yves Roignant; Nikolaos Balatsos; Andras Dinnyes; Pavel Baranov; Vincent Kelly; Ayelet Lamm; Gideon Rechavi; Mattia Pelizzola; Janis Liepins; Irina Holodnuka Kholodnyuk; Vanessa Zammit; Duncan Ayers; Finn Drablos; John Arne Dahl; Janusz Bujnicki; Carmen Jeronimo; Raquel Almeida; Monica Neagu; Marieta Costache; Jasna Bankovic; Bojana Banovic; Jan Kyselovic; Luis Miguel Valor; Stefan Selbert; Pinar Pir; Turan Demircan; Victoria Cowling; Matthias Schäfer; Walter Rossmanith; Denis Lafontaine; Alexandre David; Clement Carre; Frank Lyko; Raffael Schaffrath; Schraga Schwartz; Andre Verdel; Arne Klungland; Elzbieta Purta; Gordana Timotijevic; Fernando Cardona; Alberto Davalos; Ester Ballana; Donal O Carroll; Jernej Ule; Rupert Fray

doi:10.1080/15476286.2018.1460996

Positioning Europe for the EPITRANSCRIPTOMICS challenge

Michael F Jantsch, Alessandro Quattrone, Mary O'Connell, Mark Helm, Michaela Frye, Manuel Macias-Gonzales, Marie Ohman, Stefan Ameres, Luc Willems, Francois Fuks, Anastasis Oulas, Stepanka Vanacova, Henrik Nielsen, Cecile Bousquet-Antonelli, Yuri Motorin, Jean-Yves Roignant, Nikolaos Balatsos, Andras Dinnyes, Pavel Baranov, Vincent KellyAyelet Lamm, Gideon Rechavi, Mattia Pelizzola, Janis Liepins, Irina Holodnuka Kholodnyuk, Vanessa Zammit, Duncan Ayers, Finn Drablos, John Arne Dahl, Janusz Bujnicki, Carmen Jeronimo, Raquel Almeida, Monica Neagu, Marieta Costache, Jasna Bankovic, Bojana Banovic, Jan Kyselovic, Luis Miguel Valor, Stefan Selbert, Pinar Pir, Turan Demircan, Victoria Cowling, Matthias Schäfer, Walter Rossmanith, Denis Lafontaine, Alexandre David, Clement Carre, Frank Lyko, Raffael Schaffrath, Schraga Schwartz, Andre Verdel, Arne Klungland, Elzbieta Purta, Gordana Timotijevic, Fernando Cardona, Alberto Davalos, Ester Ballana, Donal O Carroll, Jernej Ule, Rupert Fray

Transcription, RNA, and Gene Medicine Program

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Abstract

The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.

Originalsprog	Engelsk
Tidsskrift	RNA Biology
Vol/bind	15
Udgave nummer	6
Sider (fra-til)	829-831
Antal sider	3
ISSN	1547-6286
DOI	https://doi.org/10.1080/15476286.2018.1460996
Status	Udgivet - 3 jun. 2018

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10.1080/15476286.2018.1460996Licens: CC BY-NC-ND

Positioning Europe for the EPITRANSCRIPTOMICS challengeForlagets udgivne version, 683 KBLicens: CC BY-NC-ND

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Jantsch, M. F., Quattrone, A., O'Connell, M., Helm, M., Frye, M., Macias-Gonzales, M., Ohman, M., Ameres, S., Willems, L., Fuks, F., Oulas, A., Vanacova, S., Nielsen, H., Bousquet-Antonelli, C., Motorin, Y., Roignant, J.-Y., Balatsos, N., Dinnyes, A., Baranov, P., ... Fray, R. (2018). Positioning Europe for the EPITRANSCRIPTOMICS challenge. RNA Biology, 15(6), 829-831. https://doi.org/10.1080/15476286.2018.1460996

Jantsch, MF, Quattrone, A, O'Connell, M, Helm, M, Frye, M, Macias-Gonzales, M, Ohman, M, Ameres, S, Willems, L, Fuks, F, Oulas, A, Vanacova, S, Nielsen, H, Bousquet-Antonelli, C, Motorin, Y, Roignant, J-Y, Balatsos, N, Dinnyes, A, Baranov, P, Kelly, V, Lamm, A, Rechavi, G, Pelizzola, M, Liepins, J, Holodnuka Kholodnyuk, I, Zammit, V, Ayers, D, Drablos, F, Dahl, JA, Bujnicki, J, Jeronimo, C, Almeida, R, Neagu, M, Costache, M, Bankovic, J, Banovic, B, Kyselovic, J, Valor, LM, Selbert, S, Pir, P, Demircan, T, Cowling, V, Schäfer, M, Rossmanith, W, Lafontaine, D, David, A, Carre, C, Lyko, F, Schaffrath, R, Schwartz, S, Verdel, A, Klungland, A, Purta, E, Timotijevic, G, Cardona, F, Davalos, A, Ballana, E, O Carroll, D, Ule, J & Fray, R 2018, 'Positioning Europe for the EPITRANSCRIPTOMICS challenge', RNA Biology, bind 15, nr. 6, s. 829-831. https://doi.org/10.1080/15476286.2018.1460996

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title = "Positioning Europe for the EPITRANSCRIPTOMICS challenge",

abstract = "The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.",

keywords = "DNA, Neoplasm/genetics, Epigenesis, Genetic, Epigenomics/standards, Europe, Gene Expression Profiling/methods, Gene Expression Regulation, Neoplastic, Humans, Neoplasms/genetics, RNA, Neoplasm/genetics, Transcriptome",

author = "Jantsch, {Michael F} and Alessandro Quattrone and Mary O'Connell and Mark Helm and Michaela Frye and Manuel Macias-Gonzales and Marie Ohman and Stefan Ameres and Luc Willems and Francois Fuks and Anastasis Oulas and Stepanka Vanacova and Henrik Nielsen and Cecile Bousquet-Antonelli and Yuri Motorin and Jean-Yves Roignant and Nikolaos Balatsos and Andras Dinnyes and Pavel Baranov and Vincent Kelly and Ayelet Lamm and Gideon Rechavi and Mattia Pelizzola and Janis Liepins and {Holodnuka Kholodnyuk}, Irina and Vanessa Zammit and Duncan Ayers and Finn Drablos and Dahl, {John Arne} and Janusz Bujnicki and Carmen Jeronimo and Raquel Almeida and Monica Neagu and Marieta Costache and Jasna Bankovic and Bojana Banovic and Jan Kyselovic and Valor, {Luis Miguel} and Stefan Selbert and Pinar Pir and Turan Demircan and Victoria Cowling and Matthias Sch{\"a}fer and Walter Rossmanith and Denis Lafontaine and Alexandre David and Clement Carre and Frank Lyko and Raffael Schaffrath and Schraga Schwartz and Andre Verdel and Arne Klungland and Elzbieta Purta and Gordana Timotijevic and Fernando Cardona and Alberto Davalos and Ester Ballana and {O Carroll}, Donal and Jernej Ule and Rupert Fray",

year = "2018",

month = jun,

day = "3",

doi = "10.1080/15476286.2018.1460996",

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T1 - Positioning Europe for the EPITRANSCRIPTOMICS challenge

AU - Jantsch, Michael F

AU - Quattrone, Alessandro

AU - O'Connell, Mary

AU - Helm, Mark

AU - Frye, Michaela

AU - Macias-Gonzales, Manuel

AU - Ohman, Marie

AU - Ameres, Stefan

AU - Willems, Luc

AU - Fuks, Francois

AU - Oulas, Anastasis

AU - Vanacova, Stepanka

AU - Nielsen, Henrik

AU - Bousquet-Antonelli, Cecile

AU - Motorin, Yuri

AU - Roignant, Jean-Yves

AU - Balatsos, Nikolaos

AU - Dinnyes, Andras

AU - Baranov, Pavel

AU - Kelly, Vincent

AU - Lamm, Ayelet

AU - Rechavi, Gideon

AU - Pelizzola, Mattia

AU - Liepins, Janis

AU - Holodnuka Kholodnyuk, Irina

AU - Zammit, Vanessa

AU - Ayers, Duncan

AU - Drablos, Finn

AU - Dahl, John Arne

AU - Bujnicki, Janusz

AU - Jeronimo, Carmen

AU - Almeida, Raquel

AU - Neagu, Monica

AU - Costache, Marieta

AU - Bankovic, Jasna

AU - Banovic, Bojana

AU - Kyselovic, Jan

AU - Valor, Luis Miguel

AU - Selbert, Stefan

AU - Pir, Pinar

AU - Demircan, Turan

AU - Cowling, Victoria

AU - Schäfer, Matthias

AU - Rossmanith, Walter

AU - Lafontaine, Denis

AU - David, Alexandre

AU - Carre, Clement

AU - Lyko, Frank

AU - Schaffrath, Raffael

AU - Schwartz, Schraga

AU - Verdel, Andre

AU - Klungland, Arne

AU - Purta, Elzbieta

AU - Timotijevic, Gordana

AU - Cardona, Fernando

AU - Davalos, Alberto

AU - Ballana, Ester

AU - O Carroll, Donal

AU - Ule, Jernej

AU - Fray, Rupert

PY - 2018/6/3

Y1 - 2018/6/3

N2 - The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.

AB - The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.

KW - DNA, Neoplasm/genetics

KW - Epigenesis, Genetic

KW - Epigenomics/standards

KW - Europe

KW - Gene Expression Profiling/methods

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Neoplasms/genetics

KW - RNA, Neoplasm/genetics

KW - Transcriptome

U2 - 10.1080/15476286.2018.1460996

DO - 10.1080/15476286.2018.1460996

M3 - Comment/debate

C2 - 29671387

SN - 1547-6286

VL - 15

SP - 829

EP - 831

JO - RNA Biology

JF - RNA Biology

IS - 6

ER -

Positioning Europe for the EPITRANSCRIPTOMICS challenge

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