Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens

TY - JOUR

T1 - Position paper of the EAACI

T2 - food allergy due to immunological cross-reactions with common inhalant allergens

AU - Werfel, T

AU - Asero, R

AU - Ballmer-Weber, B K

AU - Beyer, K

AU - Enrique, E

AU - Knulst, A C

AU - Mari, A

AU - Muraro, A

AU - Ollert, M

AU - Poulsen, L K

AU - Vieths, S

AU - Worm, M

AU - Hoffmann-Sommergruber, K

N1 - © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - In older children, adolescents, and adults, a substantial part of all IgE-mediated food allergies is caused by cross-reacting allergenic structures shared by inhalants and foods. IgE stimulated by a cross-reactive inhalant allergen can result in diverse patterns of allergic reactions to various foods. Local, mild, or severe systemic reactions may occur already after the first consumption of a food containing a cross-reactive allergen. In clinical practice, clinically relevant sensitizations are elucidated by skin prick testing or by the determination of specific IgE in vitro. Component-resolved diagnosis may help to reach a diagnosis and may predict the risk of a systemic reaction. Allergy needs to be confirmed in cases of unclear history by oral challenge tests. The therapeutic potential of allergen immunotherapy with inhalant allergens in pollen-related food allergy is not clear, and more placebo-controlled studies are needed. As we are facing an increasing incidence of pollen allergies, a shift in sensitization patterns and changes in nutritional habits, and the occurrence of new, so far unknown allergies due to cross-reactions are expected.

AB - In older children, adolescents, and adults, a substantial part of all IgE-mediated food allergies is caused by cross-reacting allergenic structures shared by inhalants and foods. IgE stimulated by a cross-reactive inhalant allergen can result in diverse patterns of allergic reactions to various foods. Local, mild, or severe systemic reactions may occur already after the first consumption of a food containing a cross-reactive allergen. In clinical practice, clinically relevant sensitizations are elucidated by skin prick testing or by the determination of specific IgE in vitro. Component-resolved diagnosis may help to reach a diagnosis and may predict the risk of a systemic reaction. Allergy needs to be confirmed in cases of unclear history by oral challenge tests. The therapeutic potential of allergen immunotherapy with inhalant allergens in pollen-related food allergy is not clear, and more placebo-controlled studies are needed. As we are facing an increasing incidence of pollen allergies, a shift in sensitization patterns and changes in nutritional habits, and the occurrence of new, so far unknown allergies due to cross-reactions are expected.

KW - Allergens

KW - Animals

KW - Cross Reactions

KW - Food Hypersensitivity

KW - Humans

KW - Inhalation

KW - Research

KW - Skin Tests

U2 - 10.1111/all.12666

DO - 10.1111/all.12666

M3 - Journal article

C2 - 26095197

SN - 0105-4538

VL - 70

SP - 1079

EP - 1090

JO - Allergy

JF - Allergy

IS - 9

ER -