Polymorphisms in the interleukin-7 receptor [alpha] gene and mortality in untreated HIV-infected individuals

Hans Jakob Hartling; Lise Wegner Th�rner; Christian Erikstrup; Rutendo Zinyama; Per Kallestrup; Exnevia Gomo; Susanne Dam Poulsen; Henrik Ullum

doi:10.1097/qad.0b013e3283606c2d

Polymorphisms in the interleukin-7 receptor [alpha] gene and mortality in untreated HIV-infected individuals

Hans Jakob Hartling, Lise Wegner Th�rner, Christian Erikstrup, Rutendo Zinyama, Per Kallestrup, Exnevia Gomo, Susanne Dam Poulsen, Henrik Ullum

Institut for Klinisk Medicin

7 Citationer (Scopus)

Abstract

Objectives: Recently, polymorphisms in the gene encoding the interleukin-7 receptor a(IL7Ra) have been shown to influence the CD4 cell count in HIV-infected individuals. The objective of this study was to examine the impact of 10 single nucleotide polymorphisms (SNPs) in or in close proximity to the IL7Ra on mortality among 152 untreated HIV infected in a Zimbabwean cohort. Methods: Patients were followed prospectively, median time of follow-up 3.9 year. SNPs were genotyped using competitive allele-specific PCR. Cox regression was used for survival analyses. Results: We found an increased mortality among carriers of the IL7Ra, rs6897932, T-allele (hazard ratio: 2.56 [95% confidence interval (CI) 1.22-5.35], P = 0.013). This association remained significant after adjusting for age, sex, baseline HIV-RNA and baseline CD4 cell count (hazard ratio = 2.36 (95% CI 1.06-2.58), P= 0.036). Conclusion: The results suggest an association between the IL7Ra, rs6897932, T-allele and increased mortality among untreated HIV-infected, Zimbabwean individuals.

Originalsprog	Engelsk
Tidsskrift	AIDS
Vol/bind	27
Udgave nummer	10
Sider (fra-til)	1615-1620
Antal sider	6
ISSN	0269-9370
DOI	https://doi.org/10.1097/qad.0b013e3283606c2d
Status	Udgivet - 19 jun. 2013

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10.1097/qad.0b013e3283606c2d

https://pdfs.journals.lww.com/aidsonline/2013/06190/Polymorphisms_in_the_interleukin_7_receptor___gene.10.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1541439720240;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdN2ziiHhY6wPF9tfA80junl15nJle1zJyVggahrEk60Y=;hash|XL8gzmkVjXMAMAJbBYq1Nw==

Citationsformater

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title = "Polymorphisms in the interleukin-7 receptor [alpha] gene and mortality in untreated HIV-infected individuals",

abstract = "Objectives: Recently, polymorphisms in the gene encoding the interleukin-7 receptor a(IL7Ra) have been shown to influence the CD4 cell count in HIV-infected individuals. The objective of this study was to examine the impact of 10 single nucleotide polymorphisms (SNPs) in or in close proximity to the IL7Ra on mortality among 152 untreated HIV infected in a Zimbabwean cohort. Methods: Patients were followed prospectively, median time of follow-up 3.9 year. SNPs were genotyped using competitive allele-specific PCR. Cox regression was used for survival analyses. Results: We found an increased mortality among carriers of the IL7Ra, rs6897932, T-allele (hazard ratio: 2.56 [95% confidence interval (CI) 1.22-5.35], P = 0.013). This association remained significant after adjusting for age, sex, baseline HIV-RNA and baseline CD4 cell count (hazard ratio = 2.36 (95% CI 1.06-2.58), P= 0.036). Conclusion: The results suggest an association between the IL7Ra, rs6897932, T-allele and increased mortality among untreated HIV-infected, Zimbabwean individuals.",

author = "Hartling, {Hans Jakob} and Th�rner, {Lise Wegner} and Christian Erikstrup and Rutendo Zinyama and Per Kallestrup and Exnevia Gomo and Poulsen, {Susanne Dam} and Henrik Ullum",

year = "2013",

month = jun,

day = "19",

doi = "10.1097/qad.0b013e3283606c2d",

language = "English",

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TY - JOUR

T1 - Polymorphisms in the interleukin-7 receptor [alpha] gene and mortality in untreated HIV-infected individuals

AU - Hartling, Hans Jakob

AU - Th�rner, Lise Wegner

AU - Erikstrup, Christian

AU - Zinyama, Rutendo

AU - Kallestrup, Per

AU - Gomo, Exnevia

AU - Poulsen, Susanne Dam

AU - Ullum, Henrik

PY - 2013/6/19

Y1 - 2013/6/19

N2 - Objectives: Recently, polymorphisms in the gene encoding the interleukin-7 receptor a(IL7Ra) have been shown to influence the CD4 cell count in HIV-infected individuals. The objective of this study was to examine the impact of 10 single nucleotide polymorphisms (SNPs) in or in close proximity to the IL7Ra on mortality among 152 untreated HIV infected in a Zimbabwean cohort. Methods: Patients were followed prospectively, median time of follow-up 3.9 year. SNPs were genotyped using competitive allele-specific PCR. Cox regression was used for survival analyses. Results: We found an increased mortality among carriers of the IL7Ra, rs6897932, T-allele (hazard ratio: 2.56 [95% confidence interval (CI) 1.22-5.35], P = 0.013). This association remained significant after adjusting for age, sex, baseline HIV-RNA and baseline CD4 cell count (hazard ratio = 2.36 (95% CI 1.06-2.58), P= 0.036). Conclusion: The results suggest an association between the IL7Ra, rs6897932, T-allele and increased mortality among untreated HIV-infected, Zimbabwean individuals.

AB - Objectives: Recently, polymorphisms in the gene encoding the interleukin-7 receptor a(IL7Ra) have been shown to influence the CD4 cell count in HIV-infected individuals. The objective of this study was to examine the impact of 10 single nucleotide polymorphisms (SNPs) in or in close proximity to the IL7Ra on mortality among 152 untreated HIV infected in a Zimbabwean cohort. Methods: Patients were followed prospectively, median time of follow-up 3.9 year. SNPs were genotyped using competitive allele-specific PCR. Cox regression was used for survival analyses. Results: We found an increased mortality among carriers of the IL7Ra, rs6897932, T-allele (hazard ratio: 2.56 [95% confidence interval (CI) 1.22-5.35], P = 0.013). This association remained significant after adjusting for age, sex, baseline HIV-RNA and baseline CD4 cell count (hazard ratio = 2.36 (95% CI 1.06-2.58), P= 0.036). Conclusion: The results suggest an association between the IL7Ra, rs6897932, T-allele and increased mortality among untreated HIV-infected, Zimbabwean individuals.

U2 - 10.1097/qad.0b013e3283606c2d

DO - 10.1097/qad.0b013e3283606c2d

M3 - Journal article

C2 - 23462217

SN - 0269-9370

VL - 27

SP - 1615

EP - 1620

JO - AIDS

JF - AIDS

IS - 10

ER -

Polymorphisms in the interleukin-7 receptor [alpha] gene and mortality in untreated HIV-infected individuals

Abstract

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