Pleomorphic adenoma of the parotid gland 1985-2010: A Danish nationwide study of incidence, recurrence rate, and malignant transformation

TY - JOUR

T1 - Pleomorphic adenoma of the parotid gland 1985-2010

T2 - A Danish nationwide study of incidence, recurrence rate, and malignant transformation

AU - Andreasen, Simon

AU - Therkildsen, Marianne H

AU - Bjørndal, Kristine

AU - Homøe, Preben

N1 - © 2015 Wiley Periodicals, Inc.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background Pleomorphic adenoma is the most frequent salivary gland tumor and is known for its tendency to recur and for its ability to transform to carcinoma ex pleomorphic adenoma (Ca-ex-PA). Along with pleomorphic adenoma demographics, we present the first nationwide study with long-term follow-up on these topics. Methods The Danish Pathology Data Bank was searched for parotid pleomorphic adenoma and Ca-ex-PA in the period 1985 to 2010 and all pathology descriptions were reviewed. Ca-ex-PA specimens were reviewed by a pathologist. Results A total of 5.497 patients were identified and 2.86% had at least one recurrence. An incidence of 4.29/100,000/year was found. The rate of malignant transformation in recurrent pleomorphic adenoma was 3.3%. Conclusion We report an up-to-date assessment of the epidemiology of pleomorphic adenoma. We found an increasing incidence and low recurrence rate compared with previous studies. The risk of Ca-ex-PA for patients with recurrent pleomorphic adenoma was low compared to the literature.

AB - Background Pleomorphic adenoma is the most frequent salivary gland tumor and is known for its tendency to recur and for its ability to transform to carcinoma ex pleomorphic adenoma (Ca-ex-PA). Along with pleomorphic adenoma demographics, we present the first nationwide study with long-term follow-up on these topics. Methods The Danish Pathology Data Bank was searched for parotid pleomorphic adenoma and Ca-ex-PA in the period 1985 to 2010 and all pathology descriptions were reviewed. Ca-ex-PA specimens were reviewed by a pathologist. Results A total of 5.497 patients were identified and 2.86% had at least one recurrence. An incidence of 4.29/100,000/year was found. The rate of malignant transformation in recurrent pleomorphic adenoma was 3.3%. Conclusion We report an up-to-date assessment of the epidemiology of pleomorphic adenoma. We found an increasing incidence and low recurrence rate compared with previous studies. The risk of Ca-ex-PA for patients with recurrent pleomorphic adenoma was low compared to the literature.

KW - Journal Article

U2 - 10.1002/hed.24228

DO - 10.1002/hed.24228

M3 - Journal article

C2 - 26382619

SN - 1043-3074

VL - 38

SP - E1364-9

JO - Head & Neck - Journal for the Sciences and Specialties of the Head and Neck

JF - Head & Neck - Journal for the Sciences and Specialties of the Head and Neck

IS - Suppl 1

ER -