Plasma levels of glucagon like peptide-1 associate with diastolic function in elderly men

TY - JOUR

T1 - Plasma levels of glucagon like peptide-1 associate with diastolic function in elderly men

AU - Nathanson, D

AU - Zethelius, B

AU - Berne, C

AU - Lind, L

AU - Andrén, B

AU - Ingelsson, E

AU - Holst, Jens Juul

AU - Nyström, T

N1 - © 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK.

PY - 2011/3

Y1 - 2011/3

N2 - Aims Congestive heart failure is a major cause of morbidity and mortality in diabetes. Besides the glycaemic effects of glucagon-like peptide1 (GLP-1) mimetics, their effects on the heart are of interest. Methods We aimed to investigate longitudinal relationships between plasma levels of fasting GLP-1 (fGLP-1), 60-min oral glucose tolerance test-stimulated GLP-1 levels (60GLP-1), and the dynamic GLP-1 response after oral glucose tolerance test (ΔGLP-1=60GLP-1-fGLP-1) and incidence of hospitalized congestive heart failure, during a follow-up time of a maximum of 9.8years in 71-year-old men. We also investigated, cross-sectionally, the association between GLP-1 and left ventricular function as estimated by echocardiography. Results During the follow-up period, 16 of 290 participants with normal glucose tolerance experienced a congestive heart failure event (rate 0.7/100person-years at risk), as did eight of 136 participants (rate 0.8/100person-years at risk) with impaired glucose tolerance and nine of 72 participants (rate 1.7/100person-years at risk) with Type2 diabetes mellitus. Although GLP-1 concentrations did not predict congestive heart failure (fGLP-1: HR0.98, 95%CI0.4-2.4; 60GLP-1: HR1.1, 95%CI0.4-2.6; ΔGLP-1: HR0.9, 95%CI0.3-2.3), there was an association between left ventricular diastolic function (E/A ratio) and fGLP-1 (r=0.19, P=0.001), 60GLP-1 (r=0.20, P<0.001) and ΔGLP-1 (r=0.18, P=0.004). There was a lack of differences in plasma levels of GLP-1 between the groups with Type2 diabetes and normal glucose tolerance. Conclusions There were no longitudinal associations between GLP-1 levels and incidence of hospitalization for congestive heart failure. However, without any causality proven, GLP-1 levels did correlate, cross-sectionally, with left ventricular diastolic function in this cohort, suggesting that pathways including GLP-1 might be involved in the regulation of cardiac diastolic function.

AB - Aims Congestive heart failure is a major cause of morbidity and mortality in diabetes. Besides the glycaemic effects of glucagon-like peptide1 (GLP-1) mimetics, their effects on the heart are of interest. Methods We aimed to investigate longitudinal relationships between plasma levels of fasting GLP-1 (fGLP-1), 60-min oral glucose tolerance test-stimulated GLP-1 levels (60GLP-1), and the dynamic GLP-1 response after oral glucose tolerance test (ΔGLP-1=60GLP-1-fGLP-1) and incidence of hospitalized congestive heart failure, during a follow-up time of a maximum of 9.8years in 71-year-old men. We also investigated, cross-sectionally, the association between GLP-1 and left ventricular function as estimated by echocardiography. Results During the follow-up period, 16 of 290 participants with normal glucose tolerance experienced a congestive heart failure event (rate 0.7/100person-years at risk), as did eight of 136 participants (rate 0.8/100person-years at risk) with impaired glucose tolerance and nine of 72 participants (rate 1.7/100person-years at risk) with Type2 diabetes mellitus. Although GLP-1 concentrations did not predict congestive heart failure (fGLP-1: HR0.98, 95%CI0.4-2.4; 60GLP-1: HR1.1, 95%CI0.4-2.6; ΔGLP-1: HR0.9, 95%CI0.3-2.3), there was an association between left ventricular diastolic function (E/A ratio) and fGLP-1 (r=0.19, P=0.001), 60GLP-1 (r=0.20, P<0.001) and ΔGLP-1 (r=0.18, P=0.004). There was a lack of differences in plasma levels of GLP-1 between the groups with Type2 diabetes and normal glucose tolerance. Conclusions There were no longitudinal associations between GLP-1 levels and incidence of hospitalization for congestive heart failure. However, without any causality proven, GLP-1 levels did correlate, cross-sectionally, with left ventricular diastolic function in this cohort, suggesting that pathways including GLP-1 might be involved in the regulation of cardiac diastolic function.

KW - Aged, 80 and over

KW - Cross-Sectional Studies

KW - Diabetes Mellitus, Type 2

KW - Diastole

KW - Fasting

KW - Glucagon-Like Peptide 1

KW - Glucose Clamp Technique

KW - Glucose Tolerance Test

KW - Heart Failure

KW - Humans

KW - Male

KW - Prospective Studies

KW - Survival Analysis

U2 - 10.1111/j.1464-5491.2010.03207.x

DO - 10.1111/j.1464-5491.2010.03207.x

M3 - Journal article

C2 - 21309838

SN - 0742-3071

VL - 28

SP - 301

EP - 305

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 3

ER -