Physical activity, sedentary time, and sleep and the association with inflammatory markers and adiponectin in 8- to 11-year-old Danish children

TY - JOUR

T1 - Physical activity, sedentary time, and sleep and the association with inflammatory markers and adiponectin in 8- to 11-year-old Danish children

AU - Nielsen, Mette Søndergaard

AU - Quist, Jonas Salling

AU - Chaput, Jean-Philippe

AU - Dalskov, Stine-Mathilde

AU - Damsgaard, Camilla Trab

AU - Ritz, Christian

AU - Astrup, Arne

AU - Michaelsen, Kim F.

AU - Sjödin, Anders Mikael

AU - Hjorth, Mads Fiil

N1 - CURIS 2016 NEXS 231

PY - 2016/7

Y1 - 2016/7

N2 - Background: Inflammatory markers, adiponectin, and movement/nonmovement behaviors have all been linked to risk factors for cardiovascular disease; however, the association between childhood movement/nonmovement behaviors and inflammatory markers and adiponectin is unknown. Methods: We explored the association between accelerometer determined moderate-to-vigorous physical activity (MVPA), sedentary time, and sleep (7 days/8 nights) and fasting C-reactive protein (CRP), interleukin-6 (IL-6), and adiponectin in 806 school children. A sleep variability score was calculated. Results: MVPA was negatively associated with adiponectin in boys and girls (P < .001) and with CRP and IL-6 in girls (P < .05) independent of sleep duration, sedentary time, age, fat mass index (FMI), and pubertal status. Sedentary time was positively associated with adiponectin in boys and girls (both P < .001), and sleep duration with adiponectin in boys independent of age, FMI, and pubertal status (P < .001); however, these associations disappeared after mutual adjustments for movement behavior. Sleep duration variability was positively associated with CRP in girls independent of all covariates (P < .01). Conclusion: MVPA remained negatively associated with inflammatory markers and adiponectin, and sleep duration variability positively associated with CRP after adjustment for FMI, pubertal status, and other movement behavior. The inverse association between MVPA and adiponectin conflicts with the anti-inflammatory properties of adiponectin.

AB - Background: Inflammatory markers, adiponectin, and movement/nonmovement behaviors have all been linked to risk factors for cardiovascular disease; however, the association between childhood movement/nonmovement behaviors and inflammatory markers and adiponectin is unknown. Methods: We explored the association between accelerometer determined moderate-to-vigorous physical activity (MVPA), sedentary time, and sleep (7 days/8 nights) and fasting C-reactive protein (CRP), interleukin-6 (IL-6), and adiponectin in 806 school children. A sleep variability score was calculated. Results: MVPA was negatively associated with adiponectin in boys and girls (P < .001) and with CRP and IL-6 in girls (P < .05) independent of sleep duration, sedentary time, age, fat mass index (FMI), and pubertal status. Sedentary time was positively associated with adiponectin in boys and girls (both P < .001), and sleep duration with adiponectin in boys independent of age, FMI, and pubertal status (P < .001); however, these associations disappeared after mutual adjustments for movement behavior. Sleep duration variability was positively associated with CRP in girls independent of all covariates (P < .01). Conclusion: MVPA remained negatively associated with inflammatory markers and adiponectin, and sleep duration variability positively associated with CRP after adjustment for FMI, pubertal status, and other movement behavior. The inverse association between MVPA and adiponectin conflicts with the anti-inflammatory properties of adiponectin.

U2 - 10.1123/jpah.2015-0123

DO - 10.1123/jpah.2015-0123

M3 - Journal article

C2 - 26800571

SN - 1543-3080

VL - 13

SP - 733

EP - 739

JO - Journal of Physical Activity & Health

JF - Journal of Physical Activity & Health

IS - 7

ER -