Phospholipases A2 in ocular homeostasis and diseases

Jinmei Wang; Miriam Kolko; Miriam Kolko

doi:10.1016/j.biochi.2010.04.007

Phospholipases A2 in ocular homeostasis and diseases

Jinmei Wang, Miriam Kolko, Miriam Kolko

15 Citationer (Scopus)

Abstract

Phospholipases A(2) (PLA(2)s) and its generation of second messengers play an important role in signal transduction, cell proliferation, cell survival and gene expression. At low concentrations mediators of PLA(2) activity have a variety of physiological effects whereas high levels of PLA(2) and its metabolites are generated during pathological conditions. The eye is an immunoprivileged organ with tight barriers and a complex interplay among various cell types. Overall, vision is a complex process which requires a clear corneal surface and lens, and thereby a clear pathway through the eye into the retina. In the retina the photoreceptors transmit light into neuronal signals that are finally transferred to the brain to perceive an image. Growing knowledge of a role of PLA(2) in ocular diseases appears and the present review aims to summarize the vast literature on PLA(2) in the normal eye as well as during pathological conditions.

Originalsprog	Engelsk
Tidsskrift	Biochimie
Vol/bind	92
Udgave nummer	6
Sider (fra-til)	611-9
Antal sider	9
ISSN	0300-9084
DOI	https://doi.org/10.1016/j.biochi.2010.04.007
Status	Udgivet - jun. 2010

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10.1016/j.biochi.2010.04.007

Citationsformater

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title = "Phospholipases A2 in ocular homeostasis and diseases",

abstract = "Phospholipases A(2) (PLA(2)s) and its generation of second messengers play an important role in signal transduction, cell proliferation, cell survival and gene expression. At low concentrations mediators of PLA(2) activity have a variety of physiological effects whereas high levels of PLA(2) and its metabolites are generated during pathological conditions. The eye is an immunoprivileged organ with tight barriers and a complex interplay among various cell types. Overall, vision is a complex process which requires a clear corneal surface and lens, and thereby a clear pathway through the eye into the retina. In the retina the photoreceptors transmit light into neuronal signals that are finally transferred to the brain to perceive an image. Growing knowledge of a role of PLA(2) in ocular diseases appears and the present review aims to summarize the vast literature on PLA(2) in the normal eye as well as during pathological conditions.",

keywords = "Animals, Corneal Diseases, Eye Diseases, Homeostasis, Humans, Neurons, Phospholipases A2, Photoreceptor Cells, Retina, Signal Transduction",

author = "Jinmei Wang and Miriam Kolko and Miriam Kolko",

year = "2010",

month = jun,

doi = "10.1016/j.biochi.2010.04.007",

language = "English",

volume = "92",

pages = "611--9",

journal = "Biochimie",

issn = "0300-9084",

publisher = "Elsevier Masson",

number = "6",

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TY - JOUR

T1 - Phospholipases A2 in ocular homeostasis and diseases

AU - Wang, Jinmei

AU - Kolko, Miriam

PY - 2010/6

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N2 - Phospholipases A(2) (PLA(2)s) and its generation of second messengers play an important role in signal transduction, cell proliferation, cell survival and gene expression. At low concentrations mediators of PLA(2) activity have a variety of physiological effects whereas high levels of PLA(2) and its metabolites are generated during pathological conditions. The eye is an immunoprivileged organ with tight barriers and a complex interplay among various cell types. Overall, vision is a complex process which requires a clear corneal surface and lens, and thereby a clear pathway through the eye into the retina. In the retina the photoreceptors transmit light into neuronal signals that are finally transferred to the brain to perceive an image. Growing knowledge of a role of PLA(2) in ocular diseases appears and the present review aims to summarize the vast literature on PLA(2) in the normal eye as well as during pathological conditions.

AB - Phospholipases A(2) (PLA(2)s) and its generation of second messengers play an important role in signal transduction, cell proliferation, cell survival and gene expression. At low concentrations mediators of PLA(2) activity have a variety of physiological effects whereas high levels of PLA(2) and its metabolites are generated during pathological conditions. The eye is an immunoprivileged organ with tight barriers and a complex interplay among various cell types. Overall, vision is a complex process which requires a clear corneal surface and lens, and thereby a clear pathway through the eye into the retina. In the retina the photoreceptors transmit light into neuronal signals that are finally transferred to the brain to perceive an image. Growing knowledge of a role of PLA(2) in ocular diseases appears and the present review aims to summarize the vast literature on PLA(2) in the normal eye as well as during pathological conditions.

KW - Animals

KW - Corneal Diseases

KW - Eye Diseases

KW - Homeostasis

KW - Humans

KW - Neurons

KW - Phospholipases A2

KW - Photoreceptor Cells

KW - Retina

KW - Signal Transduction

U2 - 10.1016/j.biochi.2010.04.007

DO - 10.1016/j.biochi.2010.04.007

M3 - Journal article

C2 - 20403410

SN - 0300-9084

VL - 92

SP - 611

EP - 619

JO - Biochimie

JF - Biochimie

IS - 6

ER -

Phospholipases A2 in ocular homeostasis and diseases

Abstract

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