Phosphodiesterase 5 and effects of sildenafil on cerebral arteries of man and guinea pig

Medicin og biovidenskab

• 5-((4-(diethylamino)phenyl)methyl)-1,4-dihydro-1-methyl-3-propyl-7H-pyrazolo(4,3-d)pyrimidin-7-one 35%
• 5-(2-ethoxy-5(morpholinylacetyl)phenyl)-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo(4,3-d)pyrimidin-7-one methanesulphanate monohydrate 47%
• Arteries 10%
• Basilar Artery 8%
• Cerebral Arteries 82%
• Dilatation 5%
• Endothelium 6%
• Guinea Pigs 60%
• Hydrolysis 19%
• In Vitro Techniques 5%
• Messenger RNA 3%
• Middle Cerebral Artery 7%
• Migraine Disorders 6%
• Nitric Oxide Donors 8%
• Nitroprusside 7%
• Phosphodiesterase 5 Inhibitors 17%
• Proteins 2%
• Sildenafil Citrate 86%
• Type 5 Cyclic Nucleotide Phosphodiesterases 100%
• Vascular Headaches 11%
• Vasodilation 6%