Abstract
An alternative procedure for isolation of 4β-phorbol from seeds of Croton tiglium has been developed, and an
artifact containing a furan ring formed by rearrangement of 12,13,20-O-triacylated phorbol derivatives into (6bS,7R,8R,8aS)-2-
(hydroxymethyl)-5,7,9,9-tetramethyl-3,7,8,9,9a,9b-hexahydrocyclopropa[3′,4′]benzo[1′,2′:3,4]cyclohepta[1,2-b]furan-6b,8,8atriol
(8a) has been characterized. A mechanism involving an oxidative rearrangement and a decarboxylation for formation of the
artifact is proposed.
artifact containing a furan ring formed by rearrangement of 12,13,20-O-triacylated phorbol derivatives into (6bS,7R,8R,8aS)-2-
(hydroxymethyl)-5,7,9,9-tetramethyl-3,7,8,9,9a,9b-hexahydrocyclopropa[3′,4′]benzo[1′,2′:3,4]cyclohepta[1,2-b]furan-6b,8,8atriol
(8a) has been characterized. A mechanism involving an oxidative rearrangement and a decarboxylation for formation of the
artifact is proposed.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Journal of Natural Products |
Vol/bind | 81 |
Udgave nummer | 9 |
Sider (fra-til) | 2134-2137 |
Antal sider | 4 |
ISSN | 0163-3864 |
DOI | |
Status | Udgivet - 28 sep. 2018 |
Emneord
- Det tidligere Farmaceutiske Fakultet