Phenotypes of individuals affected by airborne chemicals in the general population

TY - JOUR

T1 - Phenotypes of individuals affected by airborne chemicals in the general population

AU - Berg, Nikolaj Drimer

AU - Linneberg, A.

AU - Dirksen, Asger

AU - Elberling, J.

AU - Berg, Nikolaj Drimer

AU - Berg, N.D.

AU - Dirksen, Asger

N1 - Keywords: Adolescent; Adult; Aged; Air Pollutants; Air Pollution; Cross-Sectional Studies; Denmark; Female; Health Status; Humans; Inhalation Exposure; Logistic Models; Male; Middle Aged; Multiple Chemical Sensitivity; Phenotype; Quality of Life; Questionnaires; Young Adult

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: To characterise the chemical exposures and symptoms affecting individuals with subsequent adjustments of social life or occupational conditions, and further characterise these severely affected individuals. METHODS: All individuals (n = 1,134) who reported symptoms from airborne chemical exposures in a population-based questionnaire study of 6,000 individuals were included and dichotomised according to severity. Logistic regression models were used to characterise the group of severely affected individuals. RESULTS: Severely affected individuals reported more symptoms and exposures related to symptoms than less severely affected individuals, and the number of symptoms was more predictive for severity than the number of exposures. Most predictive for the severity of reported symptoms were CNS-symptoms other than headache (OR = 3.2, P <0.001) and exposure to freshly printed papers or magazines (OR = 2.0, P = 0.001). CONCLUSION: CNS-symptoms except from headache were a main characteristic of individuals severely affected by common chemical exposures in a general population-based sample

AB - OBJECTIVE: To characterise the chemical exposures and symptoms affecting individuals with subsequent adjustments of social life or occupational conditions, and further characterise these severely affected individuals. METHODS: All individuals (n = 1,134) who reported symptoms from airborne chemical exposures in a population-based questionnaire study of 6,000 individuals were included and dichotomised according to severity. Logistic regression models were used to characterise the group of severely affected individuals. RESULTS: Severely affected individuals reported more symptoms and exposures related to symptoms than less severely affected individuals, and the number of symptoms was more predictive for severity than the number of exposures. Most predictive for the severity of reported symptoms were CNS-symptoms other than headache (OR = 3.2, P <0.001) and exposure to freshly printed papers or magazines (OR = 2.0, P = 0.001). CONCLUSION: CNS-symptoms except from headache were a main characteristic of individuals severely affected by common chemical exposures in a general population-based sample

U2 - 10.1007/s00420-008-0352-y

DO - 10.1007/s00420-008-0352-y

M3 - Tidsskriftartikel

C2 - 18751996

SN - 0340-0131

VL - 82

SP - 509

EP - 517

JO - International Archives of Occupational and Environmental Health

JF - International Archives of Occupational and Environmental Health

IS - 4

ER -