PfEMP1 – a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis

TY - CHAP

T1 - PfEMP1 – a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis

AU - Hviid, Lars

AU - Jensen, Anja T R

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Plasmodium falciparum causes the most severe form of malaria and is responsible for essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes infected by mature P. falciparum parasites can lead to circulatory disturbances and inflammation, and is thought to be a central element in the pathogenesis of the disease. It is mediated by the interaction of parasite ligands on the erythrocyte surface and a range of host receptor molecules in many organs and tissues. Among several proteins and protein families implicated in this process, the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of high-molecular weight and highly variable antigens appears to be the most prominent. In this chapter, we aim to provide a systematic overview of the current knowledge about these proteins, their structure, their function, how they are presented on the erythrocyte surface, and how the var genes encoding them are regulated. The role of PfEMP1 in the pathogenesis of malaria, PfEMP1-specific immune responses, and the prospect of PfEMP1-specific vaccination against malaria are also covered briefly.

AB - Plasmodium falciparum causes the most severe form of malaria and is responsible for essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes infected by mature P. falciparum parasites can lead to circulatory disturbances and inflammation, and is thought to be a central element in the pathogenesis of the disease. It is mediated by the interaction of parasite ligands on the erythrocyte surface and a range of host receptor molecules in many organs and tissues. Among several proteins and protein families implicated in this process, the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of high-molecular weight and highly variable antigens appears to be the most prominent. In this chapter, we aim to provide a systematic overview of the current knowledge about these proteins, their structure, their function, how they are presented on the erythrocyte surface, and how the var genes encoding them are regulated. The role of PfEMP1 in the pathogenesis of malaria, PfEMP1-specific immune responses, and the prospect of PfEMP1-specific vaccination against malaria are also covered briefly.

U2 - 10.1016/bs.apar.2015.02.004

DO - 10.1016/bs.apar.2015.02.004

M3 - Book chapter

C2 - 25911365

VL - 88

T3 - Advances in Parasitology

SP - 51

EP - 84

BT - Advances in Parasitology

A2 - Rollinson, D.

A2 - Stothard, J.R.

ER -