PET med amyloidligander bør ikke anvendesrutinemæssigt i tidlig diagnostik af Alzheimerssygdom – en gennemgang af et Cochranereview

Steen Gregers Hasselbalch

PET med amyloidligander bør ikke anvendesrutinemæssigt i tidlig diagnostik af Alzheimerssygdom – en gennemgang af et Cochranereview

Institut for Klinisk Medicin

Abstract

Recent diagnostic criteria for Alzheimer's disease incorporate biomarkers in order to increase the diagnostic accuracy. In a recent Cochrane review the ligand (11)C-PiB showed a high sensitivity, but low specificity for detecting patients with mild cognitive impairment who would develop Alzheimer's dementia. Given the evolution of Alzheimer pathology, these findings are not surprising. With current limited treatment options for MCI, (11)C-PiB-PET cannot be recommended for routine use in MCI and should be used only in selected cases where a positive scan will alter management.

Bidragets oversatte titel	PET with amyloid ligands should not be applied routinely in early diagnostics of Alzheimer's disease
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	177
Udgave nummer	32
Sider (fra-til)	V11140610
ISSN	0041-5782
Status	Udgivet - 3 aug. 2015

Citationsformater

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abstract = "Recent diagnostic criteria for Alzheimer's disease incorporate biomarkers in order to increase the diagnostic accuracy. In a recent Cochrane review the ligand (11)C-PiB showed a high sensitivity, but low specificity for detecting patients with mild cognitive impairment who would develop Alzheimer's dementia. Given the evolution of Alzheimer pathology, these findings are not surprising. With current limited treatment options for MCI, (11)C-PiB-PET cannot be recommended for routine use in MCI and should be used only in selected cases where a positive scan will alter management.",

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N2 - Recent diagnostic criteria for Alzheimer's disease incorporate biomarkers in order to increase the diagnostic accuracy. In a recent Cochrane review the ligand (11)C-PiB showed a high sensitivity, but low specificity for detecting patients with mild cognitive impairment who would develop Alzheimer's dementia. Given the evolution of Alzheimer pathology, these findings are not surprising. With current limited treatment options for MCI, (11)C-PiB-PET cannot be recommended for routine use in MCI and should be used only in selected cases where a positive scan will alter management.

AB - Recent diagnostic criteria for Alzheimer's disease incorporate biomarkers in order to increase the diagnostic accuracy. In a recent Cochrane review the ligand (11)C-PiB showed a high sensitivity, but low specificity for detecting patients with mild cognitive impairment who would develop Alzheimer's dementia. Given the evolution of Alzheimer pathology, these findings are not surprising. With current limited treatment options for MCI, (11)C-PiB-PET cannot be recommended for routine use in MCI and should be used only in selected cases where a positive scan will alter management.

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VL - 177

SP - V11140610

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JF - Ugeskrift for Laeger

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PET med amyloidligander bør ikke anvendesrutinemæssigt i tidlig diagnostik af Alzheimerssygdom – en gennemgang af et Cochranereview

Abstract

Fingeraftryk

Citationsformater