Personalized medicine in psychiatry

Ida Kim Wium-Andersen; Maj Vinberg; Lars Vedel Kessing; Roger S. McIntyre

doi:10.1080/08039488.2016.1216163

Personalized medicine in psychiatry

Ida Kim Wium-Andersen^*, Maj Vinberg, Lars Vedel Kessing, Roger S. McIntyre

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

28 Citationer (Scopus)

Abstract

Background: Personalized medicine is a model in which a patient’s unique clinical, genetic, and environmental characteristics are the basis for treatment and prevention.

Aim, method, and results: This review aims to describe the current tools, phenomenological features, clinical risk factors, and biomarkers used to provide personalized medicine. Furthermore, this study describes the target areas in which they can be applied including diagnostics, treatment selection and response, assessment of risk of side-effects, and prevention.

Discussion and conclusion: Personalized medicine in psychiatry is challenged by the current taxonomy, where the diagnostic categories are broad and great biological heterogeneity exists within each category. There is, thus, a gap between the current advanced research prospects and clinical practice, and the current taxonomy is, thus, a poor basis for biological research. The discussion proposes possible solutions to narrow this gap and to move psychiatric research forward towards personalized medicine.

Originalsprog	Engelsk
Tidsskrift	Nordic Journal of Psychiatry
Vol/bind	71
Udgave nummer	1
Sider (fra-til)	12-19
Antal sider	8
ISSN	0803-9488
DOI	https://doi.org/10.1080/08039488.2016.1216163
Status	Udgivet - jan. 2017

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10.1080/08039488.2016.1216163

Citationsformater

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title = "Personalized medicine in psychiatry",

abstract = "Background: Personalized medicine is a model in which a patient{\textquoteright}s unique clinical, genetic, and environmental characteristics are the basis for treatment and prevention. Aim, method, and results: This review aims to describe the current tools, phenomenological features, clinical risk factors, and biomarkers used to provide personalized medicine. Furthermore, this study describes the target areas in which they can be applied including diagnostics, treatment selection and response, assessment of risk of side-effects, and prevention. Discussion and conclusion: Personalized medicine in psychiatry is challenged by the current taxonomy, where the diagnostic categories are broad and great biological heterogeneity exists within each category. There is, thus, a gap between the current advanced research prospects and clinical practice, and the current taxonomy is, thus, a poor basis for biological research. The discussion proposes possible solutions to narrow this gap and to move psychiatric research forward towards personalized medicine.",

keywords = "Biomarkers, diagnostic system, genetics, personalized medicine, psychiatry, RDoC, taxonomy",

author = "Wium-Andersen, {Ida Kim} and Maj Vinberg and Kessing, {Lars Vedel} and McIntyre, {Roger S.}",

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N2 - Background: Personalized medicine is a model in which a patient’s unique clinical, genetic, and environmental characteristics are the basis for treatment and prevention. Aim, method, and results: This review aims to describe the current tools, phenomenological features, clinical risk factors, and biomarkers used to provide personalized medicine. Furthermore, this study describes the target areas in which they can be applied including diagnostics, treatment selection and response, assessment of risk of side-effects, and prevention. Discussion and conclusion: Personalized medicine in psychiatry is challenged by the current taxonomy, where the diagnostic categories are broad and great biological heterogeneity exists within each category. There is, thus, a gap between the current advanced research prospects and clinical practice, and the current taxonomy is, thus, a poor basis for biological research. The discussion proposes possible solutions to narrow this gap and to move psychiatric research forward towards personalized medicine.

AB - Background: Personalized medicine is a model in which a patient’s unique clinical, genetic, and environmental characteristics are the basis for treatment and prevention. Aim, method, and results: This review aims to describe the current tools, phenomenological features, clinical risk factors, and biomarkers used to provide personalized medicine. Furthermore, this study describes the target areas in which they can be applied including diagnostics, treatment selection and response, assessment of risk of side-effects, and prevention. Discussion and conclusion: Personalized medicine in psychiatry is challenged by the current taxonomy, where the diagnostic categories are broad and great biological heterogeneity exists within each category. There is, thus, a gap between the current advanced research prospects and clinical practice, and the current taxonomy is, thus, a poor basis for biological research. The discussion proposes possible solutions to narrow this gap and to move psychiatric research forward towards personalized medicine.

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KW - RDoC

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Personalized medicine in psychiatry

Abstract

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