Persistente fluorforbindelser reducerer immunfunktionen

Carsten Heilmann; Lise Jensen; Pal Weihe; Flemming Nielsen; Lisbeth E. Knudsen; Esben Budtz-Jørgensen; Kåre Mølbak; Philippe Grandjean

Persistente fluorforbindelser reducerer immunfunktionen

Carsten Heilmann, Lise Jensen, Pal Weihe, Flemming Nielsen, Lisbeth E. Knudsen, Esben Budtz-Jørgensen, Kåre Mølbak, Philippe Grandjean

1 Citationer (Scopus)

Abstract

Perfluorinated compounds are highly stable and useful industrial chemicals. Both perfluorooctane sulfonic acid and perfluorooctanoic acid cause immunotoxic effects in animal models at serum concentrations similar to human levels. In children who have undergone routine vaccinations, serum concentrations of these substances are inversely associated with concentrations of antibodies against diphtheria and tetanus. Prevention of such effects will require a decrease of exposure limits by at least 100-fold. Immunotoxicity is not included in routine testing of industrial chemicals but urgently needs attention.

Bidragets oversatte titel	Persistant perfluorinated compounds cause immunotoxic effects.
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	176
Udgave nummer	7
Sider (fra-til)	660-663
Antal sider	4
ISSN	0041-5782
Status	Udgivet - 24 feb. 2014

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Citationsformater

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abstract = "Perfluorinated compounds are highly stable and useful industrial chemicals. Both perfluorooctane sulfonic acid and perfluorooctanoic acid cause immunotoxic effects in animal models at serum concentrations similar to human levels. In children who have undergone routine vaccinations, serum concentrations of these substances are inversely associated with concentrations of antibodies against diphtheria and tetanus. Prevention of such effects will require a decrease of exposure limits by at least 100-fold. Immunotoxicity is not included in routine testing of industrial chemicals but urgently needs attention.",

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T1 - Persistente fluorforbindelser reducerer immunfunktionen

AU - Heilmann, Carsten

AU - Jensen, Lise

AU - Weihe, Pal

AU - Nielsen, Flemming

AU - Knudsen, Lisbeth E.

AU - Budtz-Jørgensen, Esben

AU - Mølbak, Kåre

AU - Grandjean, Philippe

PY - 2014/2/24

Y1 - 2014/2/24

N2 - Perfluorinated compounds are highly stable and useful industrial chemicals. Both perfluorooctane sulfonic acid and perfluorooctanoic acid cause immunotoxic effects in animal models at serum concentrations similar to human levels. In children who have undergone routine vaccinations, serum concentrations of these substances are inversely associated with concentrations of antibodies against diphtheria and tetanus. Prevention of such effects will require a decrease of exposure limits by at least 100-fold. Immunotoxicity is not included in routine testing of industrial chemicals but urgently needs attention.

AB - Perfluorinated compounds are highly stable and useful industrial chemicals. Both perfluorooctane sulfonic acid and perfluorooctanoic acid cause immunotoxic effects in animal models at serum concentrations similar to human levels. In children who have undergone routine vaccinations, serum concentrations of these substances are inversely associated with concentrations of antibodies against diphtheria and tetanus. Prevention of such effects will require a decrease of exposure limits by at least 100-fold. Immunotoxicity is not included in routine testing of industrial chemicals but urgently needs attention.

M3 - Tidsskriftartikel

C2 - 25350410

SN - 0041-5782

VL - 176

SP - 660

EP - 663

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 7

ER -

Persistente fluorforbindelser reducerer immunfunktionen

Abstract

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