Persistent Plasmodium falciparum Infection in Women With an Intent to Become Pregnant as a Risk Factor for Pregnancy-associated Malaria

Nicaise Tuikue Ndam; Bernard Tornyigah; Akpéyédjé Yannelle Dossou; Guillaume Escriou; Morten A. Nielsen; Ali Salanti; Saadou Issifou; Achille Massougbodji; Jean Philippe Chippaux; Philippe Deloron

doi:10.1093/cid/ciy380

Persistent Plasmodium falciparum Infection in Women With an Intent to Become Pregnant as a Risk Factor for Pregnancy-associated Malaria

Nicaise Tuikue Ndam, Bernard Tornyigah, Akpéyédjé Yannelle Dossou, Guillaume Escriou, Morten A. Nielsen, Ali Salanti, Saadou Issifou, Achille Massougbodji, Jean Philippe Chippaux, Philippe Deloron

12 Citationer (Scopus)

Abstract

Background: Pregnant women are more susceptible to Plasmodium falciparum than before pregnancy, and infection has consequences for both mother and offspring. The World Health Organization recommends that pregnant woman in areas of transmission receive intermittent preventive treatment (IPTp) starting in the second trimester. Consequently, women are not protected during the first trimester, although P. falciparum infections are both frequent and harmful. Methods: A cohort of nulligravid women was followed up during subsequent pregnancy. Malaria was diagnosed by means of microscopy and polymerase chain reaction. Parasites were genotyped at polymorphic loci. Results: Among 275 nulligravidae enrolled, 68 women became pregnant and were followed up during pregnancy. Before pregnancy, P. falciparum prevalence rates were 15% by microscopy and 66% by polymerase chain reaction. Microscopic infection rates increased to 29% until IPTp administration, and their density increased by 20-fold. Conversely, submicroscopic infection rates decreased. After IPTp administration, all types of infections decreased, but they increased again late in pregnancy. The risk of infection during pregnancy was higher in women with a microscopic (odds ratio, 6.5; P = .047) or submicroscopic (3.06; P = .05) infection before pregnancy and was not related to the season of occurrence. Most infections during pregnancy were persistent infections acquired before pregnancy. Conclusions: Microscopic and submicroscopic malaria infections were frequent in nulligravid women from south Benin. During the first trimester of pregnancy, microscopic infections were more frequent, with a higher parasite density, and mainly derived from parasites infecting the woman before conception. Preventive strategies targeting nonpregnant women with a desire for conception need to be designed.

Originalsprog	Engelsk
Tidsskrift	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Vol/bind	67
Udgave nummer	12
Sider (fra-til)	1890-1896
Antal sider	7
ISSN	1058-4838
DOI	https://doi.org/10.1093/cid/ciy380
Status	Udgivet - 2018

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10.1093/cid/ciy380

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Tuikue Ndam, N., Tornyigah, B., Dossou, A. Y., Escriou, G., Nielsen, M. A., Salanti, A., Issifou, S., Massougbodji, A., Chippaux, J. P., & Deloron, P. (2018). Persistent Plasmodium falciparum Infection in Women With an Intent to Become Pregnant as a Risk Factor for Pregnancy-associated Malaria. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67(12), 1890-1896. https://doi.org/10.1093/cid/ciy380

Persistent Plasmodium falciparum Infection in Women With an Intent to Become Pregnant as a Risk Factor for Pregnancy-associated Malaria. / Tuikue Ndam, Nicaise; Tornyigah, Bernard; Dossou, Akpéyédjé Yannelle et al.
I: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Bind 67, Nr. 12, 2018, s. 1890-1896.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Tuikue Ndam, N, Tornyigah, B, Dossou, AY, Escriou, G, Nielsen, MA , Salanti, A, Issifou, S, Massougbodji, A, Chippaux, JP & Deloron, P 2018, 'Persistent Plasmodium falciparum Infection in Women With an Intent to Become Pregnant as a Risk Factor for Pregnancy-associated Malaria', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, bind 67, nr. 12, s. 1890-1896. https://doi.org/10.1093/cid/ciy380

@article{a84c8704b63d489baa2b6fe7bad60b0e,

title = "Persistent Plasmodium falciparum Infection in Women With an Intent to Become Pregnant as a Risk Factor for Pregnancy-associated Malaria",

abstract = "Background: Pregnant women are more susceptible to Plasmodium falciparum than before pregnancy, and infection has consequences for both mother and offspring. The World Health Organization recommends that pregnant woman in areas of transmission receive intermittent preventive treatment (IPTp) starting in the second trimester. Consequently, women are not protected during the first trimester, although P. falciparum infections are both frequent and harmful. Methods: A cohort of nulligravid women was followed up during subsequent pregnancy. Malaria was diagnosed by means of microscopy and polymerase chain reaction. Parasites were genotyped at polymorphic loci. Results: Among 275 nulligravidae enrolled, 68 women became pregnant and were followed up during pregnancy. Before pregnancy, P. falciparum prevalence rates were 15% by microscopy and 66% by polymerase chain reaction. Microscopic infection rates increased to 29% until IPTp administration, and their density increased by 20-fold. Conversely, submicroscopic infection rates decreased. After IPTp administration, all types of infections decreased, but they increased again late in pregnancy. The risk of infection during pregnancy was higher in women with a microscopic (odds ratio, 6.5; P = .047) or submicroscopic (3.06; P = .05) infection before pregnancy and was not related to the season of occurrence. Most infections during pregnancy were persistent infections acquired before pregnancy. Conclusions: Microscopic and submicroscopic malaria infections were frequent in nulligravid women from south Benin. During the first trimester of pregnancy, microscopic infections were more frequent, with a higher parasite density, and mainly derived from parasites infecting the woman before conception. Preventive strategies targeting nonpregnant women with a desire for conception need to be designed.",

author = "{Tuikue Ndam}, Nicaise and Bernard Tornyigah and Dossou, {Akp{\'e}y{\'e}dj{\'e} Yannelle} and Guillaume Escriou and Nielsen, {Morten A.} and Ali Salanti and Saadou Issifou and Achille Massougbodji and Chippaux, {Jean Philippe} and Philippe Deloron",

year = "2018",

doi = "10.1093/cid/ciy380",

language = "English",

volume = "67",

pages = "1890--1896",

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T1 - Persistent Plasmodium falciparum Infection in Women With an Intent to Become Pregnant as a Risk Factor for Pregnancy-associated Malaria

AU - Tuikue Ndam, Nicaise

AU - Tornyigah, Bernard

AU - Dossou, Akpéyédjé Yannelle

AU - Escriou, Guillaume

AU - Nielsen, Morten A.

AU - Salanti, Ali

AU - Issifou, Saadou

AU - Massougbodji, Achille

AU - Chippaux, Jean Philippe

AU - Deloron, Philippe

PY - 2018

Y1 - 2018

N2 - Background: Pregnant women are more susceptible to Plasmodium falciparum than before pregnancy, and infection has consequences for both mother and offspring. The World Health Organization recommends that pregnant woman in areas of transmission receive intermittent preventive treatment (IPTp) starting in the second trimester. Consequently, women are not protected during the first trimester, although P. falciparum infections are both frequent and harmful. Methods: A cohort of nulligravid women was followed up during subsequent pregnancy. Malaria was diagnosed by means of microscopy and polymerase chain reaction. Parasites were genotyped at polymorphic loci. Results: Among 275 nulligravidae enrolled, 68 women became pregnant and were followed up during pregnancy. Before pregnancy, P. falciparum prevalence rates were 15% by microscopy and 66% by polymerase chain reaction. Microscopic infection rates increased to 29% until IPTp administration, and their density increased by 20-fold. Conversely, submicroscopic infection rates decreased. After IPTp administration, all types of infections decreased, but they increased again late in pregnancy. The risk of infection during pregnancy was higher in women with a microscopic (odds ratio, 6.5; P = .047) or submicroscopic (3.06; P = .05) infection before pregnancy and was not related to the season of occurrence. Most infections during pregnancy were persistent infections acquired before pregnancy. Conclusions: Microscopic and submicroscopic malaria infections were frequent in nulligravid women from south Benin. During the first trimester of pregnancy, microscopic infections were more frequent, with a higher parasite density, and mainly derived from parasites infecting the woman before conception. Preventive strategies targeting nonpregnant women with a desire for conception need to be designed.

AB - Background: Pregnant women are more susceptible to Plasmodium falciparum than before pregnancy, and infection has consequences for both mother and offspring. The World Health Organization recommends that pregnant woman in areas of transmission receive intermittent preventive treatment (IPTp) starting in the second trimester. Consequently, women are not protected during the first trimester, although P. falciparum infections are both frequent and harmful. Methods: A cohort of nulligravid women was followed up during subsequent pregnancy. Malaria was diagnosed by means of microscopy and polymerase chain reaction. Parasites were genotyped at polymorphic loci. Results: Among 275 nulligravidae enrolled, 68 women became pregnant and were followed up during pregnancy. Before pregnancy, P. falciparum prevalence rates were 15% by microscopy and 66% by polymerase chain reaction. Microscopic infection rates increased to 29% until IPTp administration, and their density increased by 20-fold. Conversely, submicroscopic infection rates decreased. After IPTp administration, all types of infections decreased, but they increased again late in pregnancy. The risk of infection during pregnancy was higher in women with a microscopic (odds ratio, 6.5; P = .047) or submicroscopic (3.06; P = .05) infection before pregnancy and was not related to the season of occurrence. Most infections during pregnancy were persistent infections acquired before pregnancy. Conclusions: Microscopic and submicroscopic malaria infections were frequent in nulligravid women from south Benin. During the first trimester of pregnancy, microscopic infections were more frequent, with a higher parasite density, and mainly derived from parasites infecting the woman before conception. Preventive strategies targeting nonpregnant women with a desire for conception need to be designed.

U2 - 10.1093/cid/ciy380

DO - 10.1093/cid/ciy380

M3 - Journal article

C2 - 29733338

AN - SCOPUS:85057571327

SN - 1058-4838

VL - 67

SP - 1890

EP - 1896

JO - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

IS - 12

ER -

Persistent Plasmodium falciparum Infection in Women With an Intent to Become Pregnant as a Risk Factor for Pregnancy-associated Malaria

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