Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy

Frederikke F Rönsholt; Henrik Ullum; Terese L Katzenstein; Jan Gerstoft; Sisse R Ostrowski

doi:10.1371/journal.pone.0065182

Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy

Frederikke F Rönsholt, Henrik Ullum, Terese L Katzenstein, Jan Gerstoft, Sisse R Ostrowski

Institut for Klinisk Medicin

49 Citationer (Scopus)

Abstract

Objective:The study investigated markers of inflammation and endothelial activation in HIV infected patients after 12 years of successful combination antiretroviral treatment (cART).Methods:Inflammation and endothelial activation were assessed by measuring levels of immunoglobulins, β2-microglobulin, interleukin (IL) 8, tumor necrosis factor α (TNFα), vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1), sE-Selectin, and sP-Selectin.Results:HIV infected patients had higher levels of β2-microglobulin, IL-8, TNFα, and sICAM-1 than uninfected controls, and HIV infected patients lacked correlation between platelet counts and sP-Selectin levels found in uninfected controls.Conclusion:Discrete signs of systemic and vascular inflammation persist even after very long term cART.

Originalsprog	Engelsk
Artikelnummer	e65182
Tidsskrift	P L o S One
Vol/bind	8
Udgave nummer	6
Sider (fra-til)	1-5
Antal sider	5
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0065182
Status	Udgivet - 3 jun. 2013

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10.1371/journal.pone.0065182

Citationsformater

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title = "Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy",

abstract = "Objective:The study investigated markers of inflammation and endothelial activation in HIV infected patients after 12 years of successful combination antiretroviral treatment (cART).Methods:Inflammation and endothelial activation were assessed by measuring levels of immunoglobulins, β2-microglobulin, interleukin (IL) 8, tumor necrosis factor α (TNFα), vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1), sE-Selectin, and sP-Selectin.Results:HIV infected patients had higher levels of β2-microglobulin, IL-8, TNFα, and sICAM-1 than uninfected controls, and HIV infected patients lacked correlation between platelet counts and sP-Selectin levels found in uninfected controls.Conclusion:Discrete signs of systemic and vascular inflammation persist even after very long term cART.",

author = "R{\"o}nsholt, {Frederikke F} and Henrik Ullum and Katzenstein, {Terese L} and Jan Gerstoft and Ostrowski, {Sisse R}",

year = "2013",

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doi = "10.1371/journal.pone.0065182",

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T1 - Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy

AU - Rönsholt, Frederikke F

AU - Ullum, Henrik

AU - Katzenstein, Terese L

AU - Gerstoft, Jan

AU - Ostrowski, Sisse R

PY - 2013/6/3

Y1 - 2013/6/3

N2 - Objective:The study investigated markers of inflammation and endothelial activation in HIV infected patients after 12 years of successful combination antiretroviral treatment (cART).Methods:Inflammation and endothelial activation were assessed by measuring levels of immunoglobulins, β2-microglobulin, interleukin (IL) 8, tumor necrosis factor α (TNFα), vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1), sE-Selectin, and sP-Selectin.Results:HIV infected patients had higher levels of β2-microglobulin, IL-8, TNFα, and sICAM-1 than uninfected controls, and HIV infected patients lacked correlation between platelet counts and sP-Selectin levels found in uninfected controls.Conclusion:Discrete signs of systemic and vascular inflammation persist even after very long term cART.

AB - Objective:The study investigated markers of inflammation and endothelial activation in HIV infected patients after 12 years of successful combination antiretroviral treatment (cART).Methods:Inflammation and endothelial activation were assessed by measuring levels of immunoglobulins, β2-microglobulin, interleukin (IL) 8, tumor necrosis factor α (TNFα), vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1), sE-Selectin, and sP-Selectin.Results:HIV infected patients had higher levels of β2-microglobulin, IL-8, TNFα, and sICAM-1 than uninfected controls, and HIV infected patients lacked correlation between platelet counts and sP-Selectin levels found in uninfected controls.Conclusion:Discrete signs of systemic and vascular inflammation persist even after very long term cART.

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DO - 10.1371/journal.pone.0065182

M3 - Journal article

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SN - 1932-6203

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ER -

Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy

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