Peripheral lymphocyte subpopulations in recurrent aphthous ulceration

A Pedersen; B Klausen; H P Hougen; L P Ryder

Peripheral lymphocyte subpopulations in recurrent aphthous ulceration

A Pedersen, B Klausen, H P Hougen, L P Ryder

Afdeling for Retspatologi

16 Citationer (Scopus)

Abstract

Peripheral lymphocyte subsets--T-helper (CD4+), T-suppressor/cytotoxic (CD8+), and naive/virgin T cells/natural killer cells (CD45RA)--were studied quantitatively in 30 patients with recurrent aphthous ulceration (RAU) and 29 sex- and age-matched RAU-free control donors. The CD4+ percentage was significantly lower in the patients than in the control group (P less than 0.0001), whereas CD8+ and CD4/CD8 ratio figures did not differ significantly between patients and controls. The CD45RA+ counts were significantly higher in the patient group (P less than 0.01). The study supports previous investigations with regard to the demonstration of immunologic disturbances in RAU patients. Whether the imbalance is primary or secondary with regard to the basic etiology remains to be resolved.

Originalsprog	Engelsk
Tidsskrift	Acta Odontologica Scandinavica
Vol/bind	49
Udgave nummer	4
Sider (fra-til)	203-6
Antal sider	4
ISSN	0001-6357
Status	Udgivet - 1991

Citationsformater

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title = "Peripheral lymphocyte subpopulations in recurrent aphthous ulceration",

abstract = "Peripheral lymphocyte subsets--T-helper (CD4+), T-suppressor/cytotoxic (CD8+), and naive/virgin T cells/natural killer cells (CD45RA)--were studied quantitatively in 30 patients with recurrent aphthous ulceration (RAU) and 29 sex- and age-matched RAU-free control donors. The CD4+ percentage was significantly lower in the patients than in the control group (P less than 0.0001), whereas CD8+ and CD4/CD8 ratio figures did not differ significantly between patients and controls. The CD45RA+ counts were significantly higher in the patient group (P less than 0.01). The study supports previous investigations with regard to the demonstration of immunologic disturbances in RAU patients. Whether the imbalance is primary or secondary with regard to the basic etiology remains to be resolved.",

keywords = "Adolescent, Adult, Aged, CD4-CD8 Ratio, CD4-Positive T-Lymphocytes, Female, Humans, Killer Cells, Natural, Leukocyte Count, Male, Middle Aged, Recurrence, Stomatitis, Aphthous, T-Lymphocyte Subsets, T-Lymphocytes, Cytotoxic, T-Lymphocytes, Helper-Inducer, T-Lymphocytes, Regulatory, Time Factors",

author = "A Pedersen and B Klausen and Hougen, {H P} and Ryder, {L P}",

year = "1991",

language = "English",

volume = "49",

pages = "203--6",

journal = "Acta Odontologica Scandinavica",

issn = "0001-6357",

publisher = "Taylor & Francis",

number = "4",

}

TY - JOUR

T1 - Peripheral lymphocyte subpopulations in recurrent aphthous ulceration

AU - Pedersen, A

AU - Klausen, B

AU - Hougen, H P

AU - Ryder, L P

PY - 1991

Y1 - 1991

N2 - Peripheral lymphocyte subsets--T-helper (CD4+), T-suppressor/cytotoxic (CD8+), and naive/virgin T cells/natural killer cells (CD45RA)--were studied quantitatively in 30 patients with recurrent aphthous ulceration (RAU) and 29 sex- and age-matched RAU-free control donors. The CD4+ percentage was significantly lower in the patients than in the control group (P less than 0.0001), whereas CD8+ and CD4/CD8 ratio figures did not differ significantly between patients and controls. The CD45RA+ counts were significantly higher in the patient group (P less than 0.01). The study supports previous investigations with regard to the demonstration of immunologic disturbances in RAU patients. Whether the imbalance is primary or secondary with regard to the basic etiology remains to be resolved.

AB - Peripheral lymphocyte subsets--T-helper (CD4+), T-suppressor/cytotoxic (CD8+), and naive/virgin T cells/natural killer cells (CD45RA)--were studied quantitatively in 30 patients with recurrent aphthous ulceration (RAU) and 29 sex- and age-matched RAU-free control donors. The CD4+ percentage was significantly lower in the patients than in the control group (P less than 0.0001), whereas CD8+ and CD4/CD8 ratio figures did not differ significantly between patients and controls. The CD45RA+ counts were significantly higher in the patient group (P less than 0.01). The study supports previous investigations with regard to the demonstration of immunologic disturbances in RAU patients. Whether the imbalance is primary or secondary with regard to the basic etiology remains to be resolved.

KW - Adolescent

KW - Adult

KW - Aged

KW - CD4-CD8 Ratio

KW - CD4-Positive T-Lymphocytes

KW - Female

KW - Humans

KW - Killer Cells, Natural

KW - Leukocyte Count

KW - Male

KW - Middle Aged

KW - Recurrence

KW - Stomatitis, Aphthous

KW - T-Lymphocyte Subsets

KW - T-Lymphocytes, Cytotoxic

KW - T-Lymphocytes, Helper-Inducer

KW - T-Lymphocytes, Regulatory

KW - Time Factors

M3 - Journal article

C2 - 1681668

SN - 0001-6357

VL - 49

SP - 203

EP - 206

JO - Acta Odontologica Scandinavica

JF - Acta Odontologica Scandinavica

IS - 4

ER -

Peripheral lymphocyte subpopulations in recurrent aphthous ulceration

Abstract

Fingeraftryk

Citationsformater