Perinatal programming in offspring of diabetic mothers: Clinical data.

TY - CHAP

T1 - Perinatal programming in offspring of diabetic mothers: Clinical data.

AU - Damm, Peter

AU - Kelstrup, Louise

AU - Mathiesen, Elisabeth Reinhardt

AU - Dalsgaard Clausen, Tine

PY - 2011/11/30

Y1 - 2011/11/30

N2 - The epidemic of obesity and type 2 diabetes has a major impact on public health and underlines the urgency for identifi cation of risk groups to target preventive strategies. Studies of developmental origins of health and disease have highlighted the possible role of intrauterine exposure to maternal diabetes in the pathogenesis of overweight, type 2 diabetes, and cardiovascular disease. Furthermore, diabetes in pregnancy may also affect cognitive function in the offspring. This review primarily includes human studies of long-term implications for the offspring of maternal diabetes during pregnancy - with special focus on recent studies performed in Copenhagen. We fi nd that fetuses exposed to intrauterine hyperglycemia have a signifi cantly increased risk of development of type 2 diabetes/prediabetes, overweight, and the metabolic syndrome in childhood and adult life. Thus, based on literature and own studies, we conclude that women with gestational diabetes or type 1 diabetes during pregnancy should be informed about the excess risk of overweight, type 2 diabetes, and the metabolic syndrome in their offspring and that preventive strategies toward diabetes and cardiovascular disease are urgently needed in the next generation.

AB - The epidemic of obesity and type 2 diabetes has a major impact on public health and underlines the urgency for identifi cation of risk groups to target preventive strategies. Studies of developmental origins of health and disease have highlighted the possible role of intrauterine exposure to maternal diabetes in the pathogenesis of overweight, type 2 diabetes, and cardiovascular disease. Furthermore, diabetes in pregnancy may also affect cognitive function in the offspring. This review primarily includes human studies of long-term implications for the offspring of maternal diabetes during pregnancy - with special focus on recent studies performed in Copenhagen. We fi nd that fetuses exposed to intrauterine hyperglycemia have a signifi cantly increased risk of development of type 2 diabetes/prediabetes, overweight, and the metabolic syndrome in childhood and adult life. Thus, based on literature and own studies, we conclude that women with gestational diabetes or type 1 diabetes during pregnancy should be informed about the excess risk of overweight, type 2 diabetes, and the metabolic syndrome in their offspring and that preventive strategies toward diabetes and cardiovascular disease are urgently needed in the next generation.

M3 - Book chapter

SN - 978-3-11-024944-6

SP - 141

EP - 151

BT - Perinatal Programming. The State of the Art

A2 - Plagemann, Andreas

PB - De Gruyter

CY - Berlin, Germany

ER -