Performance of first-trimester combined screening for trisomy 13 and 18 with the double test taken at a gestational age of 8 + 0 to 13 + 6

TY - JOUR

T1 - Performance of first-trimester combined screening for trisomy 13 and 18 with the double test taken at a gestational age of 8 + 0 to 13 + 6

AU - Kirkegaard, Ida

AU - Petersen, Olav Bjørn

AU - Uldbjerg, Niels

AU - Tørring, Niels

N1 - (c) 2009 John Wiley & Sons, Ltd.

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: To evaluate the performance of the combined test for first-trimester screening for trisomy 18 and 13, when the double test is scheduled weeks before the nuchal translucency scanning.METHODS: The study included all 40 cases of trisomy 18 and 13 from April 2004 to October 2008 in a screening programme, where the double test was measured in gestational weeks 8 + 0 to 13 + 6 and the nuchal translucency in weeks 11 + 2 to 13 + 6.RESULTS: Twenty-eight among the 40 cases had complete information on all variables in the first-trimester screening test. Among 19 cases having the double test taken before 10 + 0 weeks, 10 cases were detected (detection rate (DR) = 53%) and among 9 cases having the double test taken after 10 + 0 weeks, 6 cases were detected (DR 67%). There was no significant difference in the DRs (p = 0.48). A total of 29 cases were detected at the first-trimester screening, resulting in an overall DR for trisomy 18 and 13 at 73%.CONCLUSION: This study showed no significant differences in the trisomy 18/13 DRs when grouped according to having the double test taken before or after 10 + 0 weeks. The DR was 73% at the first-trimester screening.

AB - OBJECTIVE: To evaluate the performance of the combined test for first-trimester screening for trisomy 18 and 13, when the double test is scheduled weeks before the nuchal translucency scanning.METHODS: The study included all 40 cases of trisomy 18 and 13 from April 2004 to October 2008 in a screening programme, where the double test was measured in gestational weeks 8 + 0 to 13 + 6 and the nuchal translucency in weeks 11 + 2 to 13 + 6.RESULTS: Twenty-eight among the 40 cases had complete information on all variables in the first-trimester screening test. Among 19 cases having the double test taken before 10 + 0 weeks, 10 cases were detected (detection rate (DR) = 53%) and among 9 cases having the double test taken after 10 + 0 weeks, 6 cases were detected (DR 67%). There was no significant difference in the DRs (p = 0.48). A total of 29 cases were detected at the first-trimester screening, resulting in an overall DR for trisomy 18 and 13 at 73%.CONCLUSION: This study showed no significant differences in the trisomy 18/13 DRs when grouped according to having the double test taken before or after 10 + 0 weeks. The DR was 73% at the first-trimester screening.

KW - Adult

KW - Chorionic Gonadotropin, beta Subunit, Human/blood

KW - Chromosomes, Human, Pair 13

KW - Chromosomes, Human, Pair 18

KW - Female

KW - Gestational Age

KW - Humans

KW - Middle Aged

KW - Nuchal Translucency Measurement

KW - Pregnancy

KW - Pregnancy Trimester, First/genetics

KW - Pregnancy-Associated Plasma Protein-A/analysis

KW - Retrospective Studies

KW - Trisomy/diagnosis

U2 - 10.1002/pd.2254

DO - 10.1002/pd.2254

M3 - Journal article

C2 - 19288457

SN - 0197-3851

VL - 29

SP - 582

EP - 587

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

IS - 6

ER -