Pentraxins in Complement Activation and Regulation

Ying Jie Ma; Peter Garred

doi:10.3389/fimmu.2018.03046

Pentraxins in Complement Activation and Regulation

Ying Jie Ma, Peter Garred

Institut for Klinisk Medicin

28 Citationer (Scopus)

32 Downloads (Pure)

Abstract

The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells. Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self or altered self-cells, such as C1q, collectins, ficolins, and properdin. Recent findings have interestingly shown that the pentraxins (C-reactive protein, CRP; serum-amyloid P component, SAP; long pentraxin 3, PTX3) are involved in complement activation and amplification via communication with complement initiation PRMs, but also complement regulation via recruitment of complement regulators, for instance C4b binding protein (C4BP) and factor H (fH). This review addresses the potential roles of the pentraxins in the complement system during infection and inflammation, and emphasizes the underlining implications of the pentraxins in the context of complement activation and regulation both under physiological and pathological conditions.

Originalsprog	Engelsk
Artikelnummer	3046
Tidsskrift	Frontiers in Immunology
Vol/bind	9
Antal sider	8
ISSN	1664-3224
DOI	https://doi.org/10.3389/fimmu.2018.03046
Status	Udgivet - 19 dec. 2018

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10.3389/fimmu.2018.03046Licens: CC BY

Pentraxins in Complement Activation and RegulationForlagets udgivne version, 1,53 MBLicens: CC BY

Citationsformater

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keywords = "collectin, complement activation, complement regulation, CRP, pentraxins, PTX3, SAP, the ficolins",

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AU - Garred, Peter

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AB - The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells. Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self or altered self-cells, such as C1q, collectins, ficolins, and properdin. Recent findings have interestingly shown that the pentraxins (C-reactive protein, CRP; serum-amyloid P component, SAP; long pentraxin 3, PTX3) are involved in complement activation and amplification via communication with complement initiation PRMs, but also complement regulation via recruitment of complement regulators, for instance C4b binding protein (C4BP) and factor H (fH). This review addresses the potential roles of the pentraxins in the complement system during infection and inflammation, and emphasizes the underlining implications of the pentraxins in the context of complement activation and regulation both under physiological and pathological conditions.

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KW - complement activation

KW - complement regulation

KW - CRP

KW - pentraxins

KW - PTX3

KW - SAP

KW - the ficolins

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JO - Frontiers in Immunology

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Pentraxins in Complement Activation and Regulation

Abstract

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