TY - JOUR
T1 - Patterning and shaping the endoderm in vivo and in culture
AU - Kraus, Marine R C
AU - Grapin-Botton, Anne
N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.
PY - 2012/8/1
Y1 - 2012/8/1
N2 - The definitive endoderm (DE) was first defined as the innermost germ layer found in all metazoan embryos. During development, it gives rise to a vast array of specialized epithelial cell types lining the respiratory and digestive systems, and contributes to associated organs such as thyroid, thymus, lungs, liver, and pancreas. In the adult, the DE provides a protective barrier against the environment and assumes many essential functions including digestion, nutrient absorption, and glucose homeostasis. Since general endoderm formation and patterning have been reviewed recently in a comprehensive manner [1], we will only provide a brief summary of how extracellular signals and downstream transcription factors control endoderm patterning. We will then focus on emerging work addressing the chromatin remodeling events occurring during endoderm organ specification and discuss how these molecular tools can be used to engineer endodermal organs in vitro.
AB - The definitive endoderm (DE) was first defined as the innermost germ layer found in all metazoan embryos. During development, it gives rise to a vast array of specialized epithelial cell types lining the respiratory and digestive systems, and contributes to associated organs such as thyroid, thymus, lungs, liver, and pancreas. In the adult, the DE provides a protective barrier against the environment and assumes many essential functions including digestion, nutrient absorption, and glucose homeostasis. Since general endoderm formation and patterning have been reviewed recently in a comprehensive manner [1], we will only provide a brief summary of how extracellular signals and downstream transcription factors control endoderm patterning. We will then focus on emerging work addressing the chromatin remodeling events occurring during endoderm organ specification and discuss how these molecular tools can be used to engineer endodermal organs in vitro.
U2 - 10.1016/j.gde.2012.05.002
DO - 10.1016/j.gde.2012.05.002
M3 - Review
C2 - 22742850
SN - 0959-437X
VL - 22
SP - 347
EP - 353
JO - Current Opinion in Genetics & Development
JF - Current Opinion in Genetics & Development
IS - 4
ER -