Patients with Rosacea Have Increased Risk of Depression and Anxiety Disorders: A Danish Nationwide Cohort Study

TY - JOUR

T1 - Patients with Rosacea Have Increased Risk of Depression and Anxiety Disorders

T2 - A Danish Nationwide Cohort Study

AU - Egeberg, Alexander

AU - Hansen, Peter Riis

AU - Gislason, Gunnar Hilmar

AU - Thyssen, Jacob Pontoppidan

N1 - © 2016 S. Karger AG, Basel.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - BACKGROUND: Rosacea is a chronic skin condition that affects self-esteem and quality of life. However, data on depression and anxiety in patients with rosacea are scarce.OBJECTIVE: The aim of this study was to investigate the relationship between rosacea and new-onset depression and anxiety disorders.METHODS: Data on all Danish citizens aged ≥18 years between January 1, 1997, and December 31, 2011, were linked at individual level in nationwide registers. Incidence rates per 1,000 person-years were calculated, and crude and adjusted incidence rate ratios (IRRs) with 95% confidence intervals (95% CIs) were estimated by Poisson regression models.RESULTS: The study comprised a total of 4,632,341 individuals, including 30,725 and 24,712 patients with mild and moderate-to-severe rosacea, respectively. Mild and moderate-to-severe rosacea increased the risk of both depression [IRR 1.89 (95% CI 1.82-1.96) and IRR 2.04 (95% CI 1.96-2.12)] and anxiety disorders [IRR 1.80 (95% CI 1.75-1.86) and IRR 1.98 (95% CI 1.91-2.05)].CONCLUSIONS: Rosacea was associated with a disease severity-dependent, increased risk of depression and anxiety disorders. The findings may call for increased awareness of psychiatric morbidity in patients with rosacea.

AB - BACKGROUND: Rosacea is a chronic skin condition that affects self-esteem and quality of life. However, data on depression and anxiety in patients with rosacea are scarce.OBJECTIVE: The aim of this study was to investigate the relationship between rosacea and new-onset depression and anxiety disorders.METHODS: Data on all Danish citizens aged ≥18 years between January 1, 1997, and December 31, 2011, were linked at individual level in nationwide registers. Incidence rates per 1,000 person-years were calculated, and crude and adjusted incidence rate ratios (IRRs) with 95% confidence intervals (95% CIs) were estimated by Poisson regression models.RESULTS: The study comprised a total of 4,632,341 individuals, including 30,725 and 24,712 patients with mild and moderate-to-severe rosacea, respectively. Mild and moderate-to-severe rosacea increased the risk of both depression [IRR 1.89 (95% CI 1.82-1.96) and IRR 2.04 (95% CI 1.96-2.12)] and anxiety disorders [IRR 1.80 (95% CI 1.75-1.86) and IRR 1.98 (95% CI 1.91-2.05)].CONCLUSIONS: Rosacea was associated with a disease severity-dependent, increased risk of depression and anxiety disorders. The findings may call for increased awareness of psychiatric morbidity in patients with rosacea.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1159/000444082

DO - 10.1159/000444082

M3 - Journal article

C2 - 26954304

SN - 1018-8665

VL - 232

SP - 208

EP - 213

JO - Dermatology

JF - Dermatology

IS - 2

ER -