TY - JOUR
T1 - Patient characteristics of olfactory neuroblastoma
T2 - experience from a tertiary cancer centre 2000-2016 covering Eastern Denmark
AU - Gram, Signe Buhl
AU - Grønhøj, Christian
AU - Mann, Henriette
AU - Jakobsen, Kathrine Kronberg
AU - Kiss, Katalin
AU - Bilde, Anders
AU - von Buchwald, Christian
N1 - © 2018 APMIS. Published by John Wiley & Sons Ltd.
PY - 2018/8
Y1 - 2018/8
N2 - The aim of this study was to report incidence and patient characteristics of olfactory neuroblastoma (ONB) at a tertiary cancer institution during a 16-year period. A retrospective review was conducted on patients with ONB treated at Rigshospitalet, Copenhagen from 2000 to 2016 covering Eastern Denmark. Patient demographics, symptoms, stage, pathology-reports, treatment, and outcome were extracted from the patient records and the Danish pathology register. The tumours were graded both histologically and clinically using Hyam's and Kadish classifications, respectively. We identified a total of 14 patients (ten males, four females, median age 57 years, range 17-81 years). Four patients were in Kadish stage A, one stage B, and seven stage C. According to Hyam's classification, two tumours were grade I, nine grade II, and three grade III. All patients were treated with surgery, eight in combination with radiotherapy, where one received proton therapy, and one a combination with chemotherapy. At a median follow-up time of 58 months, the 5-year overall survival was 90% (95% CI 61; 99). ONB is a rare disease; complete radical surgery alone or combined with radiotherapy offered good oncologic control and outcome. Long-term follow-up of ONB should be mandatory.
AB - The aim of this study was to report incidence and patient characteristics of olfactory neuroblastoma (ONB) at a tertiary cancer institution during a 16-year period. A retrospective review was conducted on patients with ONB treated at Rigshospitalet, Copenhagen from 2000 to 2016 covering Eastern Denmark. Patient demographics, symptoms, stage, pathology-reports, treatment, and outcome were extracted from the patient records and the Danish pathology register. The tumours were graded both histologically and clinically using Hyam's and Kadish classifications, respectively. We identified a total of 14 patients (ten males, four females, median age 57 years, range 17-81 years). Four patients were in Kadish stage A, one stage B, and seven stage C. According to Hyam's classification, two tumours were grade I, nine grade II, and three grade III. All patients were treated with surgery, eight in combination with radiotherapy, where one received proton therapy, and one a combination with chemotherapy. At a median follow-up time of 58 months, the 5-year overall survival was 90% (95% CI 61; 99). ONB is a rare disease; complete radical surgery alone or combined with radiotherapy offered good oncologic control and outcome. Long-term follow-up of ONB should be mandatory.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
KW - Denmark
KW - Esthesioneuroblastoma, Olfactory/mortality
KW - Female
KW - Gamma Rays/therapeutic use
KW - Hospitals, University
KW - Humans
KW - Male
KW - Middle Aged
KW - Nasal Cavity/drug effects
KW - Neoplasm Grading
KW - Neoplasm Staging
KW - Nose Neoplasms/mortality
KW - Prognosis
KW - Registries
KW - Retrospective Studies
KW - Survival Analysis
U2 - 10.1111/apm.12859
DO - 10.1111/apm.12859
M3 - Journal article
C2 - 30168622
SN - 0903-4641
VL - 126
SP - 663
EP - 666
JO - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
IS - 8
ER -
