TY - JOUR
T1 - Parkinson's disease and mitochondrial gene variations
T2 - A review
AU - Andalib, Sasan
AU - Vafaee, Manouchehr Seyedi
AU - Gjedde, Albert
N1 - Copyright © 2014 Elsevier B.V. All rights reserved.
PY - 2014/11/15
Y1 - 2014/11/15
N2 - Parkinson's disease (PD) is a common disorder of the central nervous system in the elderly. The pathogenesis of PD is a complex process, with genetics as an important contributing factor. This factor may stem from mitochondrial gene variations and mutations as well as from nuclear gene variations and mutations. More recently, a particular role of mitochondrial dysfunction has been suggested, arising from mitochondrial DNA variations or acquired mutations in PD pathogenesis. The present review summarizes and weighs the evidence in support of mitochondrial DNA (mtDNA) variations as important contributors to the development and course of PD.
AB - Parkinson's disease (PD) is a common disorder of the central nervous system in the elderly. The pathogenesis of PD is a complex process, with genetics as an important contributing factor. This factor may stem from mitochondrial gene variations and mutations as well as from nuclear gene variations and mutations. More recently, a particular role of mitochondrial dysfunction has been suggested, arising from mitochondrial DNA variations or acquired mutations in PD pathogenesis. The present review summarizes and weighs the evidence in support of mitochondrial DNA (mtDNA) variations as important contributors to the development and course of PD.
U2 - 10.1016/j.jns.2014.07.067
DO - 10.1016/j.jns.2014.07.067
M3 - Journal article
C2 - 25151610
SN - 0022-510X
VL - 346
SP - 11
EP - 19
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -