Pancreatic Islet Cell Tumors

Ulrich Knigge; Mikkel Andreassen; Birgitte Federspiel; Carsten Palnæs Hansen; Andreas Kjær; Seppo W. Langer

doi:10.1016/B978-0-12-801238-3.95812-4

Pancreatic Islet Cell Tumors

Ulrich Knigge, Mikkel Andreassen, Birgitte Federspiel, Carsten Palnæs Hansen, Andreas Kjær, Seppo W. Langer

Abstract

The incidence of pancreatic neuroendocrine neoplasms is more than 0.5/100.000. They are divided into Grade 1 (Ki67 < 2%), Grade 2 (Ki67 3%-20%), and Grade 3 (Ki67 > 20%). Tumors may be functioning (25%), that is, induce a hormone specific syndrome, or nonfunctioning (75%). Diagnosis is documented by histology, biochemistry, and somatostatin receptor imaging with CT (PET-CT). Surgery is the only treatment able to cure the patient. In patients with disseminated disease somatostatin analogs, interferon-alpha, everolimus or sunitinib is indicated in patients with a Ki67 < 20% and chemotherapy in patients with a Ki67 > 10%. Peptide receptor radionuclide therapy is an option in patients with disseminated disease and a Ki67 < 30%. Life-long follow-up is indicated in most patients.

Originalsprog	Engelsk
Titel	Encyclopedia of Endocrine Diseases
Redaktører	Ilpo Huhtaniemi, Luciano Martini
Forlag	Elsevier
Publikationsdato	1 jan. 2018
Udgave	2.
Sider	626-634
ISBN (Trykt)	9780128122006
DOI	https://doi.org/10.1016/B978-0-12-801238-3.95812-4
Status	Udgivet - 1 jan. 2018

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10.1016/B978-0-12-801238-3.95812-4

Citationsformater

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AU - Knigge, Ulrich

AU - Andreassen, Mikkel

AU - Federspiel, Birgitte

AU - Hansen, Carsten Palnæs

AU - Kjær, Andreas

AU - Langer, Seppo W.

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AB - The incidence of pancreatic neuroendocrine neoplasms is more than 0.5/100.000. They are divided into Grade 1 (Ki67 < 2%), Grade 2 (Ki67 3%-20%), and Grade 3 (Ki67 > 20%). Tumors may be functioning (25%), that is, induce a hormone specific syndrome, or nonfunctioning (75%). Diagnosis is documented by histology, biochemistry, and somatostatin receptor imaging with CT (PET-CT). Surgery is the only treatment able to cure the patient. In patients with disseminated disease somatostatin analogs, interferon-alpha, everolimus or sunitinib is indicated in patients with a Ki67 < 20% and chemotherapy in patients with a Ki67 > 10%. Peptide receptor radionuclide therapy is an option in patients with disseminated disease and a Ki67 < 30%. Life-long follow-up is indicated in most patients.

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Pancreatic Islet Cell Tumors

Abstract

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