TY - JOUR
T1 - Oxyntomodulin
T2 - actions and role in diabetes
AU - Holst, Jens J.
AU - Albrechtsen, Nicolai J. Wewer
AU - Gabe, Maria Buur Nordskov
AU - Rosenkilde, Mette Marie
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Oxyntomodulin is a product of the glucagon precursor, proglucagon, produced and released from the endocrine L-cells of the gut after enzymatic processing by the precursor prohormone convertase 1/3. It corresponds to the proglucagon sequence 33-69 and thus contains the entire glucagon sequence plus a C-terminal octapeptide, comprising in total 37 amino acids. As might have been expected, it has glucagon-like bioactivity, but also and more surprisingly also activates the receptor for GLP-1. This has given the molecule an interesting status as a glucagon-GLP-1 co-agonist, which is currently attracting considerable interest for its potential in the treatment of diabetes and obesity. Here, we provide an update on oxyntomodulin with a focus on its potential role in metabolic diseases.
AB - Oxyntomodulin is a product of the glucagon precursor, proglucagon, produced and released from the endocrine L-cells of the gut after enzymatic processing by the precursor prohormone convertase 1/3. It corresponds to the proglucagon sequence 33-69 and thus contains the entire glucagon sequence plus a C-terminal octapeptide, comprising in total 37 amino acids. As might have been expected, it has glucagon-like bioactivity, but also and more surprisingly also activates the receptor for GLP-1. This has given the molecule an interesting status as a glucagon-GLP-1 co-agonist, which is currently attracting considerable interest for its potential in the treatment of diabetes and obesity. Here, we provide an update on oxyntomodulin with a focus on its potential role in metabolic diseases.
KW - Journal Article
KW - Review
KW - Diabetes
KW - Oxyntomodulin
KW - Proglucagon
U2 - 10.1016/j.peptides.2017.09.018
DO - 10.1016/j.peptides.2017.09.018
M3 - Review
C2 - 29412831
SN - 0196-9781
VL - 100
SP - 48
EP - 53
JO - Peptides
JF - Peptides
ER -
